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Catalyst-free synthesis of 1,2,4,5-tetrasubstituted imidazoles from arylamins, benzonitriles, arylglyoxals, and Meldrum’s acid
Tetrahedron Letters ( IF 1.8 ) Pub Date : 2018-03-31 , DOI: 10.1016/j.tetlet.2018.03.093 Hossein Mehrabi , Farzaneh Alizadeh-Bami , Reza Ranjbar-Karimi
中文翻译:
由芳烃,苯甲腈,芳基乙二醛和Meldrum's酸无催化剂合成1,2,4,5-四取代的咪唑
更新日期:2018-03-31
Tetrahedron Letters ( IF 1.8 ) Pub Date : 2018-03-31 , DOI: 10.1016/j.tetlet.2018.03.093 Hossein Mehrabi , Farzaneh Alizadeh-Bami , Reza Ranjbar-Karimi
An efficient and catalyst-free for the synthesis of 1,2,4,5-tetrasubstituted imidazoles has been developed using a one-pot, two-step reaction of arylamins, benzonitriles, arylglyoxals, and Meldrum’s acid. All the products were obtained in good to excellent yields and their structures were established from their spectroscopic data.
中文翻译:
由芳烃,苯甲腈,芳基乙二醛和Meldrum's酸无催化剂合成1,2,4,5-四取代的咪唑
已经开发了一种高效,无催化剂的1,2,4,5-四取代的咪唑合成方法,该方法使用了芳烃,苯甲腈,芳基乙二醛和Meldrum's酸的一锅两步反应。获得的所有产品均具有良好至极好的收率,并根据其光谱数据确定了其结构。