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Central fatigue theory and endurance exercise: Toward an interoceptive model
Neuroscience & Biobehavioral Reviews ( IF 8.2 ) Pub Date : 2018-03-30 , DOI: 10.1016/j.neubiorev.2018.03.024
Terry McMorris , Martin Barwood , Jo Corbett

We propose a model of exercise-induced central fatigue based on interoception and motivation. Predictions of the expected sensory feedback are fed forward by the dorsolateral (DL) prefrontal cortex (PFC) to the anterior insula cortex (AIC). During exercise, the AIC receives feedback from lamina Ⅰ lateral spinothalamic and nucleus tractus solitarii medullothalamic pathways. The feedback is compared to the predictions in order to generate a current awareness state, which is forwarded to the anterior cingulate cortex (ACC), ventromedial (VM)PFC and lateral (L)PFC. The LPFC integrates the information and makes a decision as to whether to continue or stop. The decision is dependent upon interaction with the substantia nigra pars compacta and ventral tegmental area dopamine (DA), and locus coeruleus (LC)-norepinephrine (NE) systems. Phasic activation of DA and NE neurons appears to be necessary for maintenance of goal-related action but the VMPFC and ACC, which project to the LC, induce tonic NE activity when the rewards are thought to be not worth the cost thus fatigue is perceived.



中文翻译:

中枢疲劳理论与耐力运动:建立一种感知模型

我们提出了一种基于互感和动机的运动诱发的中央疲劳模型。预期的感觉反馈的预测由背外侧(DL)前额叶皮层(PFC)前馈至前岛叶皮层(AIC)。在运动过程中,AIC会收到来自Ⅰ类椎板外侧丘脑和髓核髓质途径的反馈。将该反馈与预测进行比较,以生成当前的感知状态,该状态会转发到前扣带回皮质(ACC),腹膜(VM)PFC和外侧(L)PFC。LPFC整合信息并决定是继续还是停止。该决定取决于与黑质致密部和腹侧被盖区多巴胺(DA)以及蓝斑脑(LC)-去甲肾上腺素(NE)系统的相互作用。

更新日期:2018-03-30
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