It is well established that aberrant cellular biochemical activity is strongly linked to the formation and progression of various cancers. Assays that could aid in cancer diagnostics, assessing anticancer drug resistance, and in the discovery of new anticancer drugs are highly warranted. In recent years, a large number of small molecule-based fluorescent chemosensors have been developed for monitoring the activity of enzymes and small biomolecular constituents. These probes have shown several advantages over traditional methods, such as the ability to directly and selectively measure activity of their targets within complex cellular environments. This review will summarize recently developed fluorescent chemosensors that have potential applications in the field of cancer biology.

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荧光化学传感器可作为癌症生物学的未来工具

公认的是，异常的细胞生化活性与各种癌症的形成和发展密切相关。极有必要进行有助于癌症诊断，评估抗癌药耐药性以及发现新抗癌药的测定方法。近年来，已经开发了许多基于小分子的荧光化学传感器，用于监测酶和小生物分子成分的活性。这些探针已显示出优于传统方法的多项优势，例如能够直接和选择性地测量复杂细胞环境中其靶标的活性。这篇综述将总结最近开发的荧光化学传感器，它们在癌症生物学领域具有潜在的应用。