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A panel of recombinant Leishmania donovani cell surface and secreted proteins identifies LdBPK_323600.1 as a serological marker of symptomatic infection mBio (IF 6.4) Pub Date : 2024-04-19 Adam J. RobertsHan Boon OngSimon ClareCordelia BrandtKatherine HarcourtYegnasew TakelePrakash GhoshAngela ToeppMax WaughDaniel MatanoAnna FärnertEmily AdamsJavier MorenoMargaret MbuchiChristine PetersenDinesh MondalPascale KropfGavin J. Wright1Hull York Medical School, University of York, Heslington, York, United Kingdom2Cell Surface Signalling Laboratory, Wellcome Sanger Institute, Cambridge, United
mBio, Ahead of Print.
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Gut-associated functions are favored during microbiome assembly across a major part of C. elegans life mBio (IF 6.4) Pub Date : 2024-04-18 Johannes ZimmermannAgnes PiecykMichael SieberCarola PetersenJulia JohnkeLucas Moitinho-SilvaSven KünzelLena BluhmArne TraulsenChristoph KaletaHinrich Schulenburg1Research Group Evolutionary Ecology and Genetics, Zoological Institute, Kiel University, Kiel, Germany2Max Planck Fellow Group Antibiotic Resistance Evolution, Max Planck Institute for Evolutionary Biology, Ploen, Germany3Research Group Medical
mBio, Ahead of Print.
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HPV oncogenes expressed from only one of multiple integrated HPV DNA copies drive clonal cell expansion in cervical cancer mBio (IF 6.4) Pub Date : 2024-04-16 Lulu Yu, Vladimir Majerciak, Alexei Lobanov, Sameer Mirza, Vimla Band, Haibin Liu, Maggie Cam, Stephen H. Hughes, Douglas R. Lowy, Zhi-Ming Zheng
Persistent oncogenic HPV infections lead to viral DNA integration into the human genome and the development of cervical, anogenital, and oropharyngeal cancers. The expression of the viral E6 and E7 oncogenes plays a key role in cell transformation and ...
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The Hippo kinases control inflammatory Hippo signaling and restrict bacterial infection in phagocytes mBio (IF 6.4) Pub Date : 2024-04-16 Brendyn M. St. Louis, Sydney M. Quagliato, Yu-Ting Su, Gregory Dyson, Pei-Chung Lee
Identifying host factors involved in susceptibility to infection is fundamental for understanding host-pathogen interactions. Clinically, individuals with mutations in the MST1 gene which encodes one of the Hippo kinases experience recurrent infection. ...
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Differential stability of Gcn4p controls its cell-specific activity in differentiated yeast colonies mBio (IF 6.4) Pub Date : 2024-04-16 Libuše Váchová, Vítězslav Plocek, Jana Maršíková, Stanislava Rešetárová, Ladislava Hatáková, Zdena Palková
In nature, microbes usually live in spatially structured communities and differentiate into precisely localized, functionally specialized cells. The coordinated interplay of cells and their response to environmental changes, such as starvation, followed ...
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Fluoride export is required for the competitive fitness of pathogenic microorganisms in dental biofilm models mBio (IF 6.4) Pub Date : 2024-04-16 Aditya Banerjee, Chia-Yu Kang, Minjun An, B. Ben Koff, Sham Sunder, Anuj Kumar, Livia M. A. Tenuta, Randy B. Stockbridge
Dental caries is a globally prevalent condition that occurs when pathogenic species, including Streptococcus mutans and Candida albicans, outcompete beneficial species, such as Streptococcus gordonii, in the dental biofilm. Fluoride is routinely used in ...
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A ketogenic diet enhances fluconazole efficacy in murine models of systemic fungal infection mBio (IF 6.4) Pub Date : 2024-04-15 Julia R. PalmucciBlake E. SellsCharles D. GiamberardinoDena L. ToffalettiBaodi DaiYohannes G. AsfawLaura G. DuboisZhong LiBarbara TheriotWiley A. SchellWilliam HopeJennifer L. TenorJohn R. Perfect1Division of Infectious Diseases, Department of Medicine, Duke University School of Medicine, Durham, North Carolina, USA2Department of Medicine, Washington University in St. Louis, St. Louis, Missouri, USA3Department
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Using the pan-genomic framework for the discovery of genomic islands in the haloarchaeon Halorubrum ezzemoulense mBio (IF 6.4) Pub Date : 2024-04-15 Yutian FengDanielle ArsenaultArtemis S. LouyakisNeta Altman-PriceUri GophnaR. Thane PapkeJohann Peter Gogarten1Department of Molecular and Cell Biology, University of Connecticut, Storrs, Connecticut, USA2The Shmunis School of Biomedicine and Cancer Research, Faculty of Life Sciences, Tel Aviv University, Tel Aviv, Israel3Avinoam Adam Department of Natural Sciences, The Open University of Israel, Raanana
mBio, Ahead of Print.
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Outpatient treatment with concomitant vaccine-boosted convalescent plasma for patients with immunosuppression and COVID-19 mBio (IF 6.4) Pub Date : 2024-04-11 Juan G. RipollSidna M. Tulledge-ScheitelAnthony A. StephensonShane FordMarsha L. PikeEllen K. GormanSara N. HansonJustin E. JuskewitchAlex J. MillerSolomiia ZarembaErik A. OvromRaymund R. RazonableRavindra GaneshRyan T. HurtErin N. FischerAmber N. DerrMichele R. EberleJennifer J. LarsenChristina M. CarneyElitza S. TheelSameer A. ParikhNeil E. KayMichael J. JoynerJonathon W. Senefeld1Department of Anesthesiology
mBio, Ahead of Print.
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The potentiality of bacteria to drive SARS-CoV-2 mutation mBio (IF 6.4) Pub Date : 2024-04-09 Xiangyu Zhang, Shun Li, Mengzhou Xue
The global spread and explosive development of the SARS-CoV-2 population have brought new mutational variability into the genome, allowing the virus to spread in front of growing population immunity while maintaining or boosting replication fitness (1, 2). The genetic diversity of SARS-CoV-2 (3, 4), along with the selective pressure exerted by antiviral drugs and vaccines (5, 6), has partially facilitated
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Distinct patterns of SARS-CoV-2 BA.2.87.1 and JN.1 variants in immune evasion, antigenicity, and cell-cell fusion mBio (IF 6.4) Pub Date : 2024-04-09 Pei LiYajie LiuJulia N. FaraoneCheng Chih HsuMichelle ChambleeYi-Min ZhengClaire CarlinJoseph S. BednashJeffrey C. HorowitzRama K. MallampalliLinda J. SaifEugene M. OltzDaniel JonesJianrong LiRichard J. GuminaShan-Lu Liu1Center for Retrovirus Research, The Ohio State University, Columbus, Ohio, USA2Department of Veterinary Biosciences, The Ohio State University, Columbus, Ohio, USA3Molecular, Cellular
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Optimization of the antifungal properties of the bacterial peptide EntV by variant analysis mBio (IF 6.4) Pub Date : 2024-04-09 Shantanu GuhaShane A. CristyGiuseppe Buda De CesareMelissa R. CruzMichael C. LorenzDanielle A. Garsin1Department of Microbiology and Molecular Genetics, The University of Texas Health Science Center at Houston, Houston, Texas, USA, Judith Berman
mBio, Ahead of Print.
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The small molecule CBR-5884 inhibits the Candida albicans phosphatidylserine synthase mBio (IF 6.4) Pub Date : 2024-04-09 Yue ZhouGregory A. PhelpsMikayla M. MangrumJemma McLeishElise K. PhillipsJinchao LouChristelle F. AncajasJeffrey M. RybakPeter M. OelkersRichard E. LeeMichael D. BestTodd B. Reynolds1Department of Microbiology, University of Tennessee, Knoxville, Tennessee, USA2Department of Chemical Biology & Therapeutics, St. Jude Children’s Research Hospital, Memphis, Tennessee, USA3Graduate School of Biomedical
mBio, Ahead of Print.
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Neisseria gonorrhoeae scavenges host sialic acid for Siglec-mediated, complement-independent suppression of neutrophil activation mBio (IF 6.4) Pub Date : 2024-04-09 Amaris J. CardenasKeena S. ThomasMary W. BrodenNoel J. FerraroMarcos M. PiresConstance M. JohnGary A. JarvisAlison K. Criss1Department of Microbiology, Immunology, and Cancer Biology, University of Virginia, Charlottesville, Virginia, USA2Department of Chemistry, University of Virginia, Charlottesville, Virginia, USA3VA Medical Center and University of California, San Francisco, San Francisco, California
mBio, Ahead of Print.
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Recombinational exchange of M-fibril and T-pilus genes generates extensive cell surface diversity in the global group A Streptococcus population mBio (IF 6.4) Pub Date : 2024-04-09 Debra E. Bessen, Bernard W. Beall, Andrew Hayes, Weihua Huang, Jeanne M. DiChiara, Srinivasan Velusamy, Hervé Tettelin, Keith A. Jolley, John T. Fallon, Sopio Chochua, Mosaed S. A. Alobaidallah, Charlie Higgs, Timothy C. Barnett, John T. Steemson, Thomas Proft, Mark R. Davies
Precision in defining the variant forms of infectious agents is critical to understanding their population biology and the epidemiology of associated diseases. Group A Streptococcus (GAS) is a global pathogen that causes a wide range of diseases and ...
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Inhibition of influenza A virus and SARS-CoV-2 infection or co-infection by griffithsin and griffithsin-based bivalent entry inhibitor mBio (IF 6.4) Pub Date : 2024-04-09 Najing CaoYanxing CaiXin HuangHanxiao JiangZiqi HuangLixiao XingLu LuShibo JiangWei Xu1Key Laboratory of Medical Molecular Virology (MOE/NHC/CAMS), Shanghai Institute of Infectious Disease and Biosecurity, Shanghai Frontiers Science Center of Pathogenic Microorganisms and Infection, School of Basic Medical Sciences, Shanghai Public Health Clinical Center, Shanghai Medical College, Fudan University
mBio, Ahead of Print.
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Loss of function of metabolic traits in typhoidal Salmonella without apparent genome degradation mBio (IF 6.4) Pub Date : 2024-04-04 Leopoldo F. M. MachadoJorge E. Galán1Department of Microbial Pathogenesis, Yale School of Medicine, New Haven, Connecticut, USA, Jeff F. Miller
mBio, Ahead of Print.
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Chloroflexus aurantiacus acetyl-CoA carboxylase evolves fused biotin carboxylase and biotin carboxyl carrier protein to complete carboxylation activity mBio (IF 6.4) Pub Date : 2024-04-04 Jiejie ShenWenping WuKangle WangJingyi WuBing LiuChunyang LiZijun GongXin HongHan FangXingwei ZhangXiaoling Xu1Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Hangzhou Normal University, Hangzhou, China2Zhejiang Key Laboratory of Medical Epigenetics, Hangzhou Normal University, Hangzhou, China3The Affiliated Hospital of Hangzhou Normal University, Hangzhou Normal
mBio, Ahead of Print.
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Fragile science mBio (IF 6.4) Pub Date : 2024-04-03 Arturo CasadevallFerric C. Fang1Department of Molecular Microbiology and Immunology, Johns Hopkins School of Public Health, Baltimore, Maryland, USA2Departments of Laboratory Medicine, Pathology and Microbiology, University of Washington, Seattle, Washington, USA
mBio, Ahead of Print.
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Defective viral genomes: advances in understanding their generation, function, and impact on infection outcomes mBio (IF 6.4) Pub Date : 2024-04-03 Justin W. BrennanYan Sun1Department of Microbiology and Immunology, University of Rochester Medical Center, Rochester, New York, USA, Jacob Yount
mBio, Ahead of Print.
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Extracellular vesicles in mycobacteria: new findings in biogenesis, host-pathogen interactions, and diagnostics mBio (IF 6.4) Pub Date : 2024-04-03 Vivian C. SalgueiroCharlotte PassemarLucía Vázquez-IniestaLaura LermaAndrés FlotoRafael Prados-Rosales1Department of Preventive Medicine, Public Health, and Microbiology. School of Medicine, Universidad Autónoma de Madrid, Madrid, Spain2Cambridge Center for Lung Infection, Royal Papworth Hospital NHS Trust, Cambridge, United Kingdom, Marcio Rodrigues
mBio, Ahead of Print.
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Persistence and evolution of Pseudomonas aeruginosa following initiation of highly effective modulator therapy in cystic fibrosis mBio (IF 6.4) Pub Date : 2024-04-02 Catherine R. ArmbrusterYasmin K. HilliamAnna C. ZemkeSamar AtteihChristopher W. MarshallJohn MooreJunu KoiralaLeah KrainzJordan R. GastonStella E. LeeVaughn S. CooperJennifer M. Bomberger1Department of Microbiology and Molecular Genetics, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA2Department of Microbiology and Immunology, Geisel School of Medicine, Dartmouth College
mBio, Ahead of Print.
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PfCAP-H is essential for assembly of condensin I complex and karyokinesis during asexual proliferation of Plasmodium falciparum mBio (IF 6.4) Pub Date : 2024-04-02 Pratima GurungJames P. McGeeJeffrey D. Dvorin1Division of Infectious Diseases, Boston Children's Hospital, Boston, Massachusetts, USA2Department of Pediatrics, Harvard Medical School, Boston, Massachusetts, USA, Nirbhay Kumar
mBio, Ahead of Print.
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Metagenome diversity illuminates the origins of pathogen effectors mBio (IF 6.4) Pub Date : 2024-04-02 Stephanie S. LehmanVictoria I. VerhoeveTimothy P. DriscollJohn F. BeckmannJoseph J. Gillespie1Division of Molecular and Cellular Biology, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland, USA2Department of Microbiology and Immunology, University of Maryland School of Medicine, Baltimore, Maryland, USA3Department of Biology
mBio, Ahead of Print.
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Genomic context as well as sequence of both psr and penicillin-binding protein 5 contributes to β-lactam resistance in Enterococcus faecium mBio (IF 6.4) Pub Date : 2024-04-02 Kavindra V. SinghJessica Galloway-PeñaMaria Camila MontealegreXingxing DongBarbara E. Murray1Division of Infectious Diseases, Department of Internal Medicine, University of Texas Health Science Center, Houston, Texas, USA2Department of Microbiology and Infectious Diseases, University of Texas Health Science Center, Houston, Texas, USA, Paul M. Dunman
mBio, Ahead of Print.
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Ascitic microbiota alteration is associated with portal vein tumor thrombosis occurrence and prognosis in hepatocellular carcinoma mBio (IF 6.4) Pub Date : 2024-04-02 Yingyun GuoShan TianNa ZhanChuan LiuJiao LiJiaming HuMeiqi QiuBinglu HuangWeiguo Dong1Department of Gastroenterology, Renmin Hospital of Wuhan University, Wuhan, Hubei, China2Department of Infectious Disease, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China3Department of Pathology, Renmin Hospital of Wuhan University, Wuhan, Hubei, China4Department
mBio, Ahead of Print.
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Reduced cold tolerance of viral-infected leafhoppers attenuates viral persistent epidemics mBio (IF 6.4) Pub Date : 2024-04-02 Biao ChenGehui CaoYulu ChenTong ZhangGuohui ZhouXin Yang1Guangdong Province Key Laboratory of Microbial Signals and Disease Control, College of Plant Protection, South China Agricultural University, Guangzhou, China, Shou-Wei Ding
mBio, Ahead of Print.
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Characterization of the transcriptionally active form of dephosphorylated DctD complexed with dephospho-IIAGlc mBio (IF 6.4) Pub Date : 2024-04-02 Sebin KangBo-Ram JangKyu-Ho Lee1Department of Life Science, Sogang University, Seoul, South Korea, Paul Babitzke
mBio, Ahead of Print.
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Catabolism of germinant amino acids is required to prevent premature spore germination in Bacillus subtilis mBio (IF 6.4) Pub Date : 2024-04-02 Iqra R. KasuOctavio Reyes-MatteAlejandro Bonive-BoscanAlan I. DermanJavier Lopez-Garrido1Max Planck Institute for Evolutionary Biology, Plön, Germany, Carmen Buchrieser
mBio, Ahead of Print.
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The ICU environment contributes to the endemicity of the “Serratia marcescens complex” in the hospital setting mBio (IF 6.4) Pub Date : 2024-04-02 Sonia Aracil-GisbertMiguel D. Fernández-De-BobadillaNatalia Guerra-PintoSilvia Serrano-CallejaAna Elena Pérez-CobasCruz SorianoRaúl de PabloVal F. LanzaBlanca Pérez-VisoSandra ReutersHenrik HasmanRafael CantónFernando BaqueroTeresa M. Coque1Microbiology, Ramón y Cajal University Hospital and Ramón y Cajal Health Research Institute (IRYCIS), Madrid, Spain2Member of the ESCMID Study Group for Epidemiological
mBio, Ahead of Print.
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Differential impacts of DNA repair machinery on fluoroquinolone persisters with different chromosome abundances mBio (IF 6.4) Pub Date : 2024-04-02 Juechun Tang, Allison M. Herzfeld, Gabrielle Leon, Mark P. Brynildsen
Persisters are rare phenotypic variants in isogenic populations that survive antibiotic treatments that kill the other cells present. Evidence has accumulated that supports a role for persisters in chronic and recurrent infections. Here, we explore how an ...
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Lack of physiological evidence for cytochrome filaments functioning as conduits for extracellular electron transfer mBio (IF 6.4) Pub Date : 2024-04-02 Ingrid A. Schwarz, Baha Alsaqri, Yassir Lekbach, Kathryn Henry, Sydney Gorman, Trevor Woodard, Laura Dion, Lauren Real, Dawn E. Holmes, Jessica A. Smith, Derek R. Lovley
Unraveling microbial extracellular electron transfer mechanisms has profound implications for environmental processes and advancing biological applications. This study on Geobacter sulfurreducens challenges prevailing beliefs on cytochrome filaments as ...
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Promoter regulatory mode evolution enhances the high multidrug resistance of tmexCD1-toprJ1 mBio (IF 6.4) Pub Date : 2024-04-02 Chengzhen Wang, Jun Yang, Zeling Xu, Luchao Lv, Sheng Chen, Mei Hong, Jian-Hua Liu
As antibiotic resistance seriously challenges global health, tigecycline is one of the few effective drugs in the pipeline against infections caused by multidrug-resistant pathogens. Our previous work identified a novel tigecycline resistance efflux pump ...
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Ten promotion and tenure tips for microbiologists and immunologists mBio (IF 6.4) Pub Date : 2024-03-29 Jacob S. Yount
Thanks to a kind nomination by early-career faculty colleagues, I was recently awarded the 2023 International Cytokine and Interferon Society Mentorship Award. This recognition coincided with my promotion to full professor and involvement on promotion and tenure committees within my university and as an external evaluator. These experiences as mentor, candidate, and evaluator prompted me to compile
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Retracted and republished from: “The current state of research on influenza antiviral drug development: drugs in clinical trial and licensed drugs” mBio (IF 6.4) Pub Date : 2024-03-29 Yanbai Li, Shanshan Huo, Zhe Yin, Zuguang Tian, Fang Huang, Peng Liu, Yue Liu, Fei Yu
Influenza is an acute, contagious respiratory illness, caused by influenza viruses (IVs), that presents an increasing public health burden (1, 2). IV is a negative-sense, single-stranded RNA (ssRNA) virus of the Orthomyxovirus genus, characterized with high genetic variability, and has circulated in the human population at least since 1580 (3). IV is classified as A, B, C, and D according to the antigenicity
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Analysis of justification for author order and gender bias in author order among those contributing equally mBio (IF 6.4) Pub Date : 2024-03-29 Ellie Rose MattoonMaisha MilesNichole A. BroderickArturo Casadevall1Department of Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA2American Society for Microbiology, Washington, DC, USA3Department of Biology, Johns Hopkins University, Baltimore, Maryland, USA, Carmen Buchrieser
mBio, Ahead of Print.
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Unravelling influenza correlates of protection: lessons from human A/H1N1 Challenge mBio (IF 6.4) Pub Date : 2024-03-28 Rebecca Jane Cox, Rishi Pathirana
Understanding the correlates of protection (COP) is paramount for designing broadly protective influenza vaccines, as currently licensed influenza vaccines are only moderately effective. The human challenge model can play an important role in defining COP. Indeed, seminal human challenge studies from Hobson et al. showed an inverse correlation between protection from infection and antibodies to the
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The Staphylococcus aureus regulatory program in a human skin-like environment mBio (IF 6.4) Pub Date : 2024-03-28 Flavia G. Costa, Krista B. Mills, Heidi A. Crosby, Alexander R. Horswill
Staphylococcus aureus is the major cause of skin diseases, and its increased prevalence in skin colonization and infections present a need to understand its physiology in this environment. The work presented here outlines S. aureus upregulation of ...
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Bile-induced biofilm formation in Bacteroides thetaiotaomicron requires magnesium efflux by an RND pump mBio (IF 6.4) Pub Date : 2024-03-27 Anne-Aurélie Lopes, Sol Vendrell-Fernández, Julien Deschamps, Sonia Georgeault, Thomas Cokelaer, Romain Briandet, Jean-Marc Ghigo
Bacteroides thetaiotaomicron is a prominent member of the human gut microbiota able to degrade dietary and host polysaccharides, altogether contributing to nutrient exchange, gut function, and maturation of the host’s immune system. This obligate anaerobe ...
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Transposable elements impact the population divergence of rice blast fungus Magnaporthe oryzae mBio (IF 6.4) Pub Date : 2024-03-27 Lianyu LinTing SunJiayuan GuoLili LinMeilian ChenZhe WangJiandong BaoJustice NorvienyekuDongmei ZhangYijuan HanGuodong LuChristopher RensingHuakun ZhengZhenhui ZhongZonghua Wang1State Key Laboratory of Ecological Pest Control for Fujian and Taiwan Crops, College of Life Science, Fujian Agriculture and Forestry University, Fuzhou, China2Fuzhou Institute of Oceanography, Minjiang University, Fuzhou,
mBio, Ahead of Print.
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Enrichable consortia of microbial symbionts degrade macroalgal polysaccharides in Kyphosus fish mBio (IF 6.4) Pub Date : 2024-03-27 Aaron Oliver, Sheila Podell, Linda Wegley Kelly, Wesley J. Sparagon, Alvaro M. Plominsky, Robert S. Nelson, Lieve M. L. Laurens, Simona Augyte, Neil A. Sims, Craig E. Nelson, Eric E. Allen
Seaweed has long been considered a promising source of sustainable biomass for bioenergy and aquaculture feed, but scalable industrial methods for decomposing terrestrial compounds can struggle to break down seaweed polysaccharides efficiently due to ...
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Bordetella filamentous hemagglutinin and adenylate cyclase toxin interactions on the bacterial surface are consistent with FhaB-mediated delivery of ACT to phagocytic cells mBio (IF 6.4) Pub Date : 2024-03-27 Zachary M. NashCarol S. InatsukaPeggy A. CotterRichard M. Johnson1Department of Microbiology and Immunology, School of Medicine, University of North Carolina-Chapel Hill, Chapel Hill, North Carolina, USA2Department of Molecular, Cellular and Developmental Biology, University of California, Santa Barbara, Santa Barbara, California, USA, K. Heran Darwin
mBio, Ahead of Print.
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The human microbiota is a beneficial reservoir for SARS-CoV-2 mutations mBio (IF 6.4) Pub Date : 2024-03-26 Birong Cao, Xiaoxi Wang, Wanchao Yin, Zhaobing Gao, Bingqing Xia
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) mutations are rapidly emerging, in particular advantageous mutations in the spike (S) protein, which either increase transmissibility or lead to immune escape and are posing a major challenge to ...
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IFN-λ drives distinct lung immune landscape changes and antiviral responses in human metapneumovirus infection mBio (IF 6.4) Pub Date : 2024-03-26 Jorna SojatiOlivia B. ParksYu ZhangSara WaltersJie LanTaylor EddensDequan LouLi FanKong ChenTim D. OuryJohn V. Williams1Department of Pediatrics, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA2Department of Pulmonary, Allergy, and Critical Care Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA3Department of Pathology, University of Pittsburgh
mBio, Ahead of Print.
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Expression of the MSPDBL2 antigen in a discrete subset of Plasmodium falciparum schizonts is regulated by GDV1 but may not be linked to sexual commitment mBio (IF 6.4) Pub Date : 2024-03-26 Aline Freville, Lindsay B. Stewart, Kevin K. A. Tetteh, Moritz Treeck, Alfred Cortes, Till S. Voss, Sarah J. Tarr, David A. Baker, David J. Conway
Malaria parasites in the blood are remarkably variable, able to switch antigenic targets so they may survive within humans who have already developed specific immune responses. This is one of the challenges in developing vaccines against malaria. MSPDBL2 ...
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Altered PBP4 and GdpP functions synergistically mediate MRSA-like high-level, broad-spectrum β-lactam resistance in Staphylococcus aureus mBio (IF 6.4) Pub Date : 2024-03-26 Li-Yin LaiNidhi SatishkumarSasha CardozoVijay HemmadiLeonor B. MarquesLiusheng HuangSergio R. FilipeMariana G. PinhoHenry F. ChambersSom S. Chatterjee1Department of Microbial Pathogenesis, School of Dentistry, University of Maryland Baltimore, Baltimore, Maryland, USA2Institute of Marine and Environmental Technology (IMET), Baltimore, Maryland, USA3Instituto de Tecnologia Química e Biológica António
mBio, Ahead of Print.
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HIV-1 capsid stability and reverse transcription are finely balanced to minimize sensing of reverse transcription products via the cGAS-STING pathway mBio (IF 6.4) Pub Date : 2024-03-26 Jenna E. Eschbach, Maritza Puray-Chavez, Shawn Mohammed, Qiankun Wang, Ming Xia, Lin-Chen Huang, Liang Shan, Sebla B. Kutluay
In HIV-1 particles, the dimeric RNA genome and associated viral proteins and enzymes are encased in a proteinaceous lattice composed of the viral capsid protein. Herein, we assessed how altering the stability of this capsid lattice through orthogonal ...
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Priorities, opportunities, and challenges for integrating microorganisms into Earth system models for climate change prediction mBio (IF 6.4) Pub Date : 2024-03-25 J. T. Lennon, R. Z. Abramoff, S. D. Allison, R. M. Burckhardt, K. M. DeAngelis, J. P. Dunne, S. D. Frey, P. Friedlingstein, C. V. Hawkes, B. A. Hungate, S. Khurana, S. N. Kivlin, N. M. Levine, S. Manzoni, A. C. Martiny, J. B. H. Martiny, N. K. Nguyen, M. Rawat, D. Talmy, K. Todd-Brown, M. Vogt, W. R. Wieder, E. J. Zakem
For more than a century, scientists have been developing models to understand and predict the complexity of Earth system dynamics (1). Earth system models (ESMs) are built from a collection of submodels that represent interactions among processes occurring on land, in the oceans, and in the atmosphere. ESMs are intended to capture emergent properties and feedbacks that operate at large scales, ranging
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Retraction for Li et al., “The current state of research on influenza antiviral drug development: drugs in clinical trial and licensed drugs” mBio (IF 6.4) Pub Date : 2024-03-22 Yanbai LiShanshan HuoZhe YinZuguang TianFang HuangPeng LiuYue LiuFei Yu
mBio, Ahead of Print.
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Erratum for Karaba et al., “Endemic Human Coronavirus Antibody Levels Are Unchanged after Convalescent or Control Plasma Transfusion for Early Outpatient COVID-19 Treatment” mBio (IF 6.4) Pub Date : 2024-03-21 Andrew H. KarabaTrevor S. JohnstonEvan BeckOliver LaeyendeckerAndrea L. CoxSabra L. KleinDavid J. Sullivan
mBio, Ahead of Print.
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Cryptococcus neoformans rapidly invades the murine brain by sequential breaching of airway and endothelial tissues barriers, followed by engulfment by microglia mBio (IF 6.4) Pub Date : 2024-03-21 Vanessa I. Francis, Corin Liddle, Emma Camacho, Madhura Kulkarni, Samuel R. S. Junior, Jamie A. Harvey, Elizabeth R. Ballou, Darren D. Thomson, Gordon D. Brown, J. Marie Hardwick, Arturo Casadevall, Jonathan Witton, Carolina Coelho
Cryptococcal meningitis causes 10%–15% of AIDS-associated deaths globally. Still, brain-specific immunity to cryptococci is a conundrum. By employing innovative imaging, this study reveals what occurs during the first days of infection in brain and in ...
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Host-derived protease promotes aggregation of Staphylococcus aureus by cleaving the surface protein SasG mBio (IF 6.4) Pub Date : 2024-03-21 Heidi A. CrosbyKlara KeimJakub M. KwiecinskiChristophe J. Langouët-AstriéKaori OshimaWells B. LaRivièreEric P. SchmidtAlexander R. Horswill1Department of Immunology and Microbiology, University of Colorado School of Medicine, Aurora, Colorado, USA2Department of Microbiology, Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University, Krakow, Poland3Division of Pulmonary Sciences
mBio, Ahead of Print.
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Genome-wide profiling of Hfq-bound RNAs reveals the iron-responsive small RNA RusT in Caulobacter crescentus mBio (IF 6.4) Pub Date : 2024-03-21 Laura N. VogtGaël PanisAnna SchäpersNikolai PeschekMichaela HuberKai PapenfortPatrick H. ViollierKathrin S. Fröhlich1Institute of Microbiology, Faculty of Biological Sciences, Friedrich Schiller University, Jena, Germany2Department of Biology I, Microbiology, Ludwig-Maximilians-University Munich, Munich, Germany3Department of Microbiology and Molecular Medicine, Faculty of Medicine/Centre Médical Universitaire
mBio, Ahead of Print.
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Proteins à la carte: riboproteogenomic exploration of bacterial N-terminal proteoform expression mBio (IF 6.4) Pub Date : 2024-03-21 Igor Fijalkowski, Valdes Snauwaert, Petra Van Damme
With the emerging theme of genes within genes comprising the existence of alternative open reading frames (ORFs) generated by translation initiation at in-frame start codons, mechanisms that control the relative utilization of annotated and alternative ...
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LVS ΔcapB-vectored multiantigenic melioidosis vaccines protect against lethal respiratory Burkholderia pseudomallei challenge in highly sensitive BALB/c mice mBio (IF 6.4) Pub Date : 2024-03-21 Michael V. Tullius, Richard A. Bowen, Peter S. Back, Saša Masleša-Galić, Susana Nava, Marcus A. Horwitz
Melioidosis, a major neglected disease caused by the intracellular bacterial pathogen Burkholderia pseudomallei, is endemic in many tropical areas of the world and causes an estimated 165,000 cases and 89,000 deaths in humans annually. Moreover, B. ...
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Structural insight into Escherichia coli CsgA amyloid fibril assembly mBio (IF 6.4) Pub Date : 2024-03-19 Fan BuDerek R. DeeBin Liu1The Hormel Institute, University of Minnesota, Austin, Minnesota, USA2Faculty of Land and Food Systems, The University of British Columbia, Vancouver, British Columbia, Canada3Department of Pharmacology, University of Minnesota Medical School, Minneapolis, Minnesota, USA, Matthew R. Chapman
mBio, Ahead of Print.
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Irgm proteins attenuate inflammatory disease in mouse models of genital Chlamydia infection mBio (IF 6.4) Pub Date : 2024-03-19 Jacob DocktermanJeffrey R. ReitanoJeffrey I. EverittGraham D. WallaceMeghan HendrixGregory A. TaylorJörn Coers1Department of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, North Carolina, USA2Department of Immunology, Duke University Medical Center, Durham, North Carolina, USA3Department of Pathology, Duke University Medical Center, Durham, North Carolina, USA4Geriatric
mBio, Ahead of Print.
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Ehrlichia effector TRP120 manipulates bacteremia to facilitate tick acquisition mBio (IF 6.4) Pub Date : 2024-03-19 Tsian ZhangRory C. ChienKhemraj BudachetriMingqun LinProsper BoyakaWeiyan HuangYasuko Rikihisa1Department of Veterinary Biosciences, The Ohio State University, Columbus, Ohio, USA, Jose A. Vazquez-Boland
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Structural insights into the Clp protein degradation machinery mBio (IF 6.4) Pub Date : 2024-03-19 Xiaolong XuYanhui WangWei HuangDanyang LiZixin DengFeng Long1Department of Neurosurgery, Zhongnan Hospital of Wuhan University, School of Pharmaceutical Sciences, Wuhan University, Wuhan, China2Ministry of Education Key Laboratory of Combinatorial Biosynthesis and Drug Discovery, School of Pharmaceutical Sciences, Wuhan University, Wuhan, China3Cryo-EM Center and the Core Facility of Wuhan University
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The acyl-CoA synthetase TgACS1 allows neutral lipid metabolism and extracellular motility in Toxoplasma gondii through relocation via its peroxisomal targeting sequence (PTS) under low nutrient conditions mBio (IF 6.4) Pub Date : 2024-03-19 Sarah CharitalSerena ShunmugamSheena DassAnna Maria AlazziChristophe-Sébastien ArnoldNicholas J. KatrisSamuel DuleyNyamekye A. QuansahFabien PierrelJérôme GovinYoshiki Yamaryo-BottéCyrille Y. Botté1Apicolipid Team, Institute for Advanced Biosciences, CNRS UMR5309, INSERM U1209, Université Grenoble Alpes, Grenoble, France2Team Govin, Institute for Advanced Biosciences, CNRS UMR5309, INSERM U1209, Université
mBio, Ahead of Print.