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Assessing phage-host population dynamics by reintroducing virulent viruses to synthetic microbiomes Cell Host Microbe (IF 30.3) Pub Date : 2024-04-22 Jacob Wilde, Randy Boyes, Avery V. Robinson, Brendan A. Daisley, Alexander J. Botschner, Dylan J.L. Brettingham, Christine V. Macpherson, Elizabeth Mallory, Emma Allen-Vercoe
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The complete Kaposi sarcoma-associated herpesvirus genome induces early-onset, metastatic angiosarcoma in transgenic mice Cell Host Microbe (IF 30.3) Pub Date : 2024-04-22 Sang-Hoon Sin, Anthony B. Eason, Yongbaek Kim, Johann W. Schneider, Blossom Damania, Dirk P. Dittmer
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Burkholderia thailandensis uses a type VI secretion system to lyse protrusions without triggering host cell responses Cell Host Microbe (IF 30.3) Pub Date : 2024-04-18 Miro Thorsten Wilhelm Plum, Hoi Ching Cheung, Patricia Reist Iscar, Yahua Chen, Yunn-Hwen Gan, Marek Basler
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Crafty mimicry grants nuclear pore entry to HIV Cell Host Microbe (IF 30.3) Pub Date : 2024-04-10 Keesiang Lim, Masaharu Hazawa, Richard W. Wong
The size of the nuclear pore should, in principle, prevent HIV-1 entry. However, HIV-1 capsid is able to gain nuclear pore entry. In a recent issue of Nature, Fu et al. and Dickson et al. demonstrate that the HIV-1 capsid mimics the nuclear transport protein karyopherins to access host nuclei.
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Fusobacterium nucleatum subsp. animalis comes to the spotlight in oral diseases Cell Host Microbe (IF 30.3) Pub Date : 2024-04-10 Bibek G C, Peng Zhou, Chenggang Wu
Krieger et al.'s study in this issue of Cell Host & Microbe reveals that Fusobacterium nucleatum subsp. animalis strains, previously underestimated, are significant in disease-affected oral areas. This challenges the long-held notion of the dominance of Fusobacterium nucleatum subsp. nucleatum, reshaping our understanding of Fusobacterium distribution in the oral microbiome.
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Spatially distributed metabolites SWEETen the root for microbes Cell Host Microbe (IF 30.3) Pub Date : 2024-04-10 Xiaoyan Fan, An-Hui Ge, Ertao Wang
Limited understanding exists on the spatial configuration of underground plant-microbe interactions. In this issue of Cell Host & Microbe, Loo et al. illustrate the sugar transporter-involved interdependent interaction between root metabolites and microbial spatial colonization, providing insights into metabolic-associated organization of plant-microbe interactions.
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A layered effect in bacterial defense Cell Host Microbe (IF 30.3) Pub Date : 2024-04-10 Karina Ilchenko, Eugen Pfeifer
Defense systems that protect bacteria from invaders, such as viruses, are believed to be multi-layered and driven by interactions. In this issue of Cell Host & Microbe, Wu, Garushyants et al.1 delve into the dynamics between these safeguard mechanisms and unravel synergistic interactions.
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GOSpel for tiny allies Cell Host Microbe (IF 30.3) Pub Date : 2024-04-10 Wei Hu, Xiaofei Yu
Infant formulas are often supplemented to foster the development of a healthy gut microbiota. In this issue of Cell Host & Microbe, Heppner et al. present an elaborate clinical trial examining the impact of formula supplementation on the development and circadian rhythmicity of the microbiota during the first year of life.
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Small RNAs direct attack and defense mechanisms in a quorum sensing phage and its host Cell Host Microbe (IF 30.3) Pub Date : 2024-04-04 Marcel Sprenger, Malte Siemers, Sebastian Krautwurst, Kai Papenfort
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Diurnal rhythmicity of infant fecal microbiota and metabolites: A randomized controlled interventional trial with infant formula Cell Host Microbe (IF 30.3) Pub Date : 2024-04-02 Nina Heppner, Sandra Reitmeier, Marjolein Heddes, Michael Vig Merino, Leon Schwartz, Alexander Dietrich, Markus List, Michael Gigl, Chen Meng, Daan R. van der Veen, Melanie Schirmer, Karin Kleigrewe, Hélène Omer, Silke Kiessling, Dirk Haller
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A metagenomics pipeline reveals insertion sequence-driven evolution of the microbiota Cell Host Microbe (IF 30.3) Pub Date : 2024-04-01 Joshua M. Kirsch, Andrew J. Hryckowian, Breck A. Duerkop
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Brucella-driven host N-glycome remodeling controls infection Cell Host Microbe (IF 30.3) Pub Date : 2024-03-25 Ana-Lucia Cabello, Kelsey Wells, Wenjing Peng, Hui-Qiang Feng, Junyao Wang, Damien F. Meyer, Christophe Noroy, En-Shuang Zhao, Hao Zhang, Xueqing Li, Haowu Chang, Gabriel Gomez, Yuxin Mao, Kristin L. Patrick, Robert O. Watson, William K. Russell, Aiying Yu, Jieqiang Zhong, Fengguang Guo, Mingqian Li, Paul de Figueiredo
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A specific enterotype derived from gut microbiome of older individuals enables favorable responses to immune checkpoint blockade therapy Cell Host Microbe (IF 30.3) Pub Date : 2024-03-20 Xiaoqiang Zhu, Xiaowen Huang, Muni Hu, Rongrong Sun, Jiantao Li, Hai Wang, Xuefeng Pan, Yanru Ma, Lijun Ning, Tianying Tong, Yilu Zhou, Jinmei Ding, Ying Zhao, Baoqin Xuan, Jing-Yuan Fang, Jie Hong, Jason Wing Hon Wong, Youwei Zhang, Haoyan Chen
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Opposing diet, microbiome, and metabolite mechanisms regulate inflammatory bowel disease in a genetically susceptible host Cell Host Microbe (IF 30.3) Pub Date : 2024-03-20 Gabriel Vasconcelos Pereira, Marie Boudaud, Mathis Wolter, Celeste Alexander, Alessandro De Sciscio, Erica T. Grant, Bruno Caetano Trindade, Nicholas A. Pudlo, Shaleni Singh, Austin Campbell, Mengrou Shan, Li Zhang, Qinnan Yang, Stéphanie Willieme, Kwi Kim, Trisha Denike-Duval, Jaime Fuentes, André Bleich, Thomas M. Schmidt, Lucy Kennedy, Eric C. Martens
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Cytoplasmic calcium influx mediated by plant MLKLs confers TNL-triggered immunity Cell Host Microbe (IF 30.3) Pub Date : 2024-03-20 Qiaochu Shen, Keiichi Hasegawa, Nicole Oelerich, Anna Prakken, Lea Weiler Tersch, Junli Wang, Frowin Reichhardt, Alexandra Tersch, Je Cuan Choo, Ton Timmers, Kay Hofmann, Jane E. Parker, Jijie Chai, Takaki Maekawa
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Human cytomegalovirus degrades DMXL1 to inhibit autophagy, lysosomal acidification, and viral assembly Cell Host Microbe (IF 30.3) Pub Date : 2024-03-12 Hanqi Li, Alice Fletcher-Etherington, Leah M. Hunter, Swati Keshri, Ceri A. Fielding, Katie Nightingale, Benjamin Ravenhill, Luis Nobre, Martin Potts, Robin Antrobus, Colin M. Crump, David C. Rubinsztein, Richard J. Stanton, Michael P. Weekes
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Sugar transporters spatially organize microbiota colonization along the longitudinal root axis of Arabidopsis Cell Host Microbe (IF 30.3) Pub Date : 2024-03-12 Eliza P.-I. Loo, Paloma Durán, Tin Yau Pang, Philipp Westhoff, Chen Deng, Carlos Durán, Martin Lercher, Ruben Garrido-Oter, Wolf B. Frommer
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Longitudinal profiling of the microbiome at four body sites reveals core stability and individualized dynamics during health and disease Cell Host Microbe (IF 30.3) Pub Date : 2024-03-12 Xin Zhou, Xiaotao Shen, Jethro S. Johnson, Daniel J. Spakowicz, Melissa Agnello, Wenyu Zhou, Monica Avina, Alexander Honkala, Faye Chleilat, Shirley Jingyi Chen, Kexin Cha, Shana Leopold, Chenchen Zhu, Lei Chen, Lin Lyu, Daniel Hornburg, Si Wu, Xinyue Zhang, Chao Jiang, Liuyiqi Jiang, Michael P. Snyder
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Pathophysiology of chikungunya virus infection associated with fatal outcomes Cell Host Microbe (IF 30.3) Pub Date : 2024-03-12 William M. de Souza, Marcilio J. Fumagalli, Shirlene T.S. de Lima, Pierina L. Parise, Deyse C.M. Carvalho, Cristian Hernandez, Ronaldo de Jesus, Jeany Delafiori, Darlan S. Candido, Victor C. Carregari, Stefanie P. Muraro, Gabriela F. Souza, Leda M. Simões Mello, Ingra M. Claro, Yamilka Díaz, Rodrigo B. Kato, Lucas N. Trentin, Clauber H.S. Costa, Ana Carolina B.M. Maximo, Karene F. Cavalcante, Scott
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Stratification of Fusobacterium nucleatum by local health status in the oral cavity defines its subspecies disease association Cell Host Microbe (IF 30.3) Pub Date : 2024-03-12 Madeline Krieger, Yasser M. AbdelRahman, Dongseok Choi, Elizabeth A. Palmer, Anna Yoo, Sean McGuire, Jens Kreth, Justin Merritt
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Inflammation and bacteriophages affect DNA inversion states and functionality of the gut microbiota Cell Host Microbe (IF 30.3) Pub Date : 2024-02-28 Shaqed Carasso, Rawan Zaatry, Haitham Hajjo, Dana Kadosh-Kariti, Nadav Ben-Assa, Rawi Naddaf, Noa Mandelbaum, Sigal Pressman, Yehuda Chowers, Tal Gefen, Kate L. Jeffrey, Juan Jofre, Michael J. Coyne, Laurie E. Comstock, Itai Sharon, Naama Geva-Zatorsky
Reversible genomic DNA inversions control the expression of numerous gut bacterial molecules, but how this impacts disease remains uncertain. By analyzing metagenomic samples from inflammatory bowel disease (IBD) cohorts, we identified multiple invertible regions where a particular orientation correlated with disease. These include the promoter of polysaccharide A (PSA) of , which induces regulatory
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A conserved antigen induces respiratory Th17-mediated broad serotype protection against pneumococcal superinfection Cell Host Microbe (IF 30.3) Pub Date : 2024-02-27 Xue Liu, Laurye Van Maele, Laura Matarazzo, Daphnée Soulard, Vinicius Alves Duarte da Silva, Vincent de Bakker, Julien Dénéréaz, Florian P. Bock, Michael Taschner, Jinzhao Ou, Stephan Gruber, Victor Nizet, Jean-Claude Sirard, Jan-Willem Veening
Several vaccines targeting bacterial pathogens show reduced efficacy upon concurrent viral infection, indicating that a new vaccinology approach is required. To identify antigens for the human pathogen that are effective following influenza infection, we performed CRISPRi-seq in a murine model of superinfection and identified the conserved gene as crucial for virulence. We show that LafB is a membrane-associated
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Alistipes indistinctus-derived hippuric acid promotes intestinal urate excretion to alleviate hyperuricemia Cell Host Microbe (IF 30.3) Pub Date : 2024-02-26 Ying-Xi Xu, Lu-Di Liu, Jiang-Yuan Zhu, Shan-Shan Zhu, Bing-Qi Ye, Jia-Lu Yang, Jing-Yi Huang, Zhi-Hao Huang, Yi You, Wen-Kang Li, Jia-Lin He, Min Xia, Yan Liu
Hyperuricemia induces inflammatory arthritis and accelerates the progression of renal and cardiovascular diseases. Gut microbiota has been linked to the development of hyperuricemia through unclear mechanisms. Here, we show that the abundance and centrality of are depleted in subjects with hyperuricemia. Integrative metagenomic and metabolomic analysis identified hippuric acid as the key microbial
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Bacterial defense systems exhibit synergistic anti-phage activity Cell Host Microbe (IF 30.3) Pub Date : 2024-02-22 Yi Wu, Sofya K. Garushyants, Anne van den Hurk, Cristian Aparicio-Maldonado, Simran Krishnakant Kushwaha, Claire M. King, Yaqing Ou, Thomas C. Todeschini, Martha R.J. Clokie, Andrew D. Millard, Yilmaz Emre Gençay, Eugene V. Koonin, Franklin L. Nobrega
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XBB.1.5 monovalent mRNA vaccine booster elicits robust neutralizing antibodies against XBB subvariants and JN.1 Cell Host Microbe (IF 30.3) Pub Date : 2024-02-19 Qian Wang, Yicheng Guo, Anthony Bowen, Ian A. Mellis, Riccardo Valdez, Carmen Gherasim, Aubree Gordon, Lihong Liu, David D. Ho
COVID-19 vaccines have recently been updated to specifically encode or contain the spike protein of the SARS-CoV-2 XBB.1.5 subvariant, but their immunogenicity in humans has yet to be fully evaluated and reported, particularly against emergent viruses that are rapidly expanding. We now report that administration of an updated monovalent mRNA vaccine booster (XBB.1.5 MV) to previously uninfected individuals
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Donor-recipient intermicrobial interactions impact transfer of subspecies and fecal microbiota transplantation outcome Cell Host Microbe (IF 30.3) Pub Date : 2024-02-16 Qiyi Chen, Chunyan Wu, Jinfeng Xu, Chen Ye, Xiang Chen, Hongliang Tian, Naixin Zong, Shaoyi Zhang, Long Li, Yuan Gao, Di Zhao, Xiaoqiong Lv, Qilin Yang, Le Wang, Jiaqu Cui, Zhiliang Lin, Jubao Lu, Rong Yang, Fang Yin, Nan Qin, Ning Li, Qian Xu, Huanlong Qin
Studies on fecal microbiota transplantation (FMT) have reported inconsistent connections between clinical outcomes and donor strain engraftment. Analyses of subspecies-level crosstalk and its influences on lineage transfer in metagenomic FMT datasets have proved challenging, as single-nucleotide polymorphisms (SNPs) are generally not linked and are often absent. Here, we utilized species genome bin
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A pathway linking atopic dermatitis to skin microbes Cell Host Microbe (IF 30.3) Pub Date : 2024-02-14 Jinfang Zhu
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“Indole-gence” for the mind Cell Host Microbe (IF 30.3) Pub Date : 2024-02-14 Jordi Mayneris-Perxachs, Anna Castells-Nobau, José Manuel Fernández-Real
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Designing microbial communities to starve out invading pathogens Cell Host Microbe (IF 30.3) Pub Date : 2024-02-14 Melissa Ellermann
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Arming up against Omicron subvariants Cell Host Microbe (IF 30.3) Pub Date : 2024-02-14 Daniel M. Altmann, Rosemary J. Boyton
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Milk to mucus: How B. fragilis colonizes the gut Cell Host Microbe (IF 30.3) Pub Date : 2024-02-14 Matthew R. Olm, Noel T. Mueller
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Susceptible bacteria can survive antibiotic treatment in the mammalian gastrointestinal tract without evolving resistance Cell Host Microbe (IF 30.3) Pub Date : 2024-02-14 Marinelle Rodrigues, Parastoo Sabaeifard, Muhammed Sadik Yildiz, Adam Lyon, Laura Coughlin, Sara Ahmed, Nicole Poulides, Ahmet C. Toprak, Cassie Behrendt, Xiaoyu Wang, Marguerite Monogue, Jiwoong Kim, Shuheng Gan, Xiaowei Zhan, Laura Filkins, Noelle S. Williams, Lora V. Hooper, Andrew Y. Koh, Erdal Toprak
Antibiotic resistance and evasion are incompletely understood and complicated by the fact that murine interval dosing models do not fully recapitulate antibiotic pharmacokinetics in humans. To better understand how gastrointestinal bacteria respond to antibiotics, we colonized germ-free mice with a pan-susceptible genetically barcoded clinical isolate and administered the antibiotic cefepime via programmable
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The live biotherapeutic SYNB1353 decreases plasma methionine via directed degradation in animal models and healthy volunteers Cell Host Microbe (IF 30.3) Pub Date : 2024-02-02 Mylène Perreault, Jillian Means, Erik Gerson, Michael James, Sean Cotton, Christopher G. Bergeron, Mark Simon, Dylan Alexander Carlin, Nathan Schmidt, Theodore C. Moore, Julie Blasbalg, Neal Sondheimer, Kenneth Ndugga-Kabuye, William S. Denney, Vincent M. Isabella, David Lubkowicz, Aoife Brennan, David L. Hava
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DGK5β-derived phosphatidic acid regulates ROS production in plant immunity by stabilizing NADPH oxidase Cell Host Microbe (IF 30.3) Pub Date : 2024-02-02 Fan Qi, Jianwei Li, Yingfei Ai, Keke Shangguan, Ping Li, Fucheng Lin, Yan Liang
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Evolution of human H3N2 influenza virus receptor specificity has substantially expanded the receptor-binding domain site Cell Host Microbe (IF 30.3) Pub Date : 2024-02-01 Andrew J. Thompson, Nicholas C. Wu, Angeles Canales, Chika Kikuchi, Xueyong Zhu, Beatriz Fernández de Toro, Francisco J. Cañada, Charli Worth, Shengyang Wang, Ryan McBride, Wenjie Peng, Corwin M. Nycholat, Jesús Jiménez-Barbero, Ian A. Wilson, James C. Paulson
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Anaerobic respiration of host-derived methionine sulfoxide protects intracellular Salmonella from the phagocyte NADPH oxidase Cell Host Microbe (IF 30.3) Pub Date : 2024-02-01 Ju-Sim Kim, Lin Liu, Sashi Kant, David J. Orlicky, Siva Uppalapati, Alyssa Margolis, Bennett J. Davenport, Thomas E. Morrison, Jennifer Matsuda, Michael McClelland, Jessica Jones-Carson, Andres Vazquez-Torres
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Intestinal microbiota programming of alveolar macrophages influences severity of respiratory viral infection Cell Host Microbe (IF 30.3) Pub Date : 2024-01-30 Vu L. Ngo, Carolin M. Lieber, Hae-ji Kang, Kaori Sakamoto, Michal Kuczma, Richard K. Plemper, Andrew T. Gewirtz
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Virological characteristics of the SARS-CoV-2 BA.2.86 variant Cell Host Microbe (IF 30.3) Pub Date : 2024-01-26 Tomokazu Tamura, Keita Mizuma, Hesham Nasser, Sayaka Deguchi, Miguel Padilla-Blanco, Yoshitaka Oda, Keiya Uriu, Jarel E.M. Tolentino, Shuhei Tsujino, Rigel Suzuki, Isshu Kojima, Naganori Nao, Ryo Shimizu, Lei Wang, Masumi Tsuda, Michael Jonathan, Yusuke Kosugi, Ziyi Guo, Alfredo A. Hinay, Olivia Putri, Kei Sato
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A gut microbiota-bile acid axis promotes intestinal homeostasis upon aspirin-mediated damage Cell Host Microbe (IF 30.3) Pub Date : 2024-01-17 Ting Li, Ning Ding, Hanqing Guo, Rui Hua, Zehao Lin, Huohuan Tian, Yue Yu, Daiming Fan, Zuyi Yuan, Frank J. Gonzalez, Yue Wu
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A bacterial sialidase mediates early-life colonization by a pioneering gut commensal Cell Host Microbe (IF 30.3) Pub Date : 2024-01-15 Ekaterina Buzun, Chia-Yun Hsu, Kristija Sejane, Renee E. Oles, Adriana Vasquez Ayala, Luke R. Loomis, Jiaqi Zhao, Leigh-Ana Rossitto, Dominic M. McGrosso, David J. Gonzalez, Lars Bode, Hiutung Chu
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A Gpr35-tuned gut microbe-brain metabolic axis regulates depressive-like behavior Cell Host Microbe (IF 30.3) Pub Date : 2024-01-09 Lingsha Cheng, Haoqian Wu, Xiaoying Cai, Youying Zhang, Siqi Yu, Yuanlong Hou, Zhe Yin, Qingyuan Yan, Qiong Wang, Taipeng Sun, Guangji Wang, Yonggui Yuan, Xueli Zhang, Haiping Hao, Xiao Zheng
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Fungicide-tolerant persister formation during cryptococcal pulmonary infection Cell Host Microbe (IF 30.3) Pub Date : 2024-01-11 Weixin Ke, Yuyan Xie, Yingying Chen, Hao Ding, Leixin Ye, Haoning Qiu, Hao Li, Lanyue Zhang, Lei Chen, Xiuyun Tian, Zhenghao Shen, Zili Song, Xin Fan, Jian-Fa Zong, Zhengyan Guo, Xiaoyu Ma, Meng Xiao, Guojian Liao, Cui Hua Liu, Wen-bing Yin, Linqi Wang
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Linking microbial genes to plasma and stool metabolites uncovers host-microbial interactions underlying ulcerative colitis disease course Cell Host Microbe (IF 30.3) Pub Date : 2024-01-11 Melanie Schirmer, Martin Stražar, Julian Avila-Pacheco, Daniel F. Rojas-Tapias, Eric M. Brown, Emily Temple, Amy Deik, Kevin Bullock, Sarah Jeanfavre, Kerry Pierce, Shen Jin, Rachele Invernizzi, Marie-Madlen Pust, Zach Costliow, David R. Mack, Anne M. Griffiths, Thomas Walters, Brendan M. Boyle, Subra Kugathasan, Hera Vlamakis, Ramnik J. Xavier
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Post-pandemic memory T cell response to SARS-CoV-2 is durable, broadly targeted, and cross-reactive to the hypermutated BA.2.86 variant Cell Host Microbe (IF 30.3) Pub Date : 2024-01-10 Rofhiwa Nesamari, Millicent A. Omondi, Richard Baguma, Maxine A. Höft, Amkele Ngomti, Anathi A. Nkayi, Asiphe S. Besethi, Siyabulela F.J. Magugu, Paballo Mosala, Avril Walters, Gesina M. Clark, Mathilda Mennen, Sango Skelem, Marguerite Adriaanse, Alba Grifoni, Alessandro Sette, Roanne S. Keeton, Ntobeko A.B. Ntusi, Catherine Riou, Wendy A. Burgers
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Memory T cells effectively recognize the SARS-CoV-2 hypermutated BA.2.86 variant Cell Host Microbe (IF 30.3) Pub Date : 2024-01-10 Thomas R. Müller, Yu Gao, Jinghua Wu, Oriana Ribeiro, Puran Chen, Peter Bergman, Ola Blennow, Lotta Hansson, Stephan Mielke, Piotr Nowak, Jan Vesterbacka, Mira Akber, Gunnar Söderdahl, C.I. Edvard Smith, Karin Loré, Margaret Sällberg Chen, Per Ljungman, Hanna M. Ingelman-Sundberg, Hans-Gustaf Ljunggren, Anders Österborg, Marcus Buggert
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Skin microbe-dependent TSLP-ILC2 priming axis in early life is co-opted in allergic inflammation Cell Host Microbe (IF 30.3) Pub Date : 2024-01-09 Jimin Cha, Tae-Gyun Kim, Euihyun Bhae, Ho-Jin Gwak, Yeajin Ju, Young Ho Choe, In-Hwan Jang, Youngae Jung, Sungmin Moon, Taehyun Kim, Wuseong Lee, Jung Sun Park, Youn Wook Chung, Siyoung Yang, Yong-Kook Kang, Young-Min Hyun, Geum-Sook Hwang, Won-Jae Lee, Mina Rho, Ji-Hwan Ryu
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Another iron in C. difficile’s fire Cell Host Microbe (IF 30.3) Pub Date : 2024-01-10 Hal Drakesmith, Michael B. Zimmermann
Iron is arguably the most important nutrient in the ongoing battle between hosts and bacteria. Recently in Nature, a unique iron storage organelle, the ferrosome, was discovered in the human pathogen Clostridioides difficile.1 But what is the role of ferrosomes and how do they affect bacterial behavior and infection?
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Better than being aPARt: S. aureus itches to get close to sensory neurons Cell Host Microbe (IF 30.3) Pub Date : 2024-01-10 Zhe Chen, Sha Huang, Yanlin Su
In a recent issue of Cell, Deng et al. show that S. aureus serine protease V8 triggers itch, independent of inflammation, by activating sensory neurons through PAR1. This study presents mechanistic insights into pruritogenic bacteria and their interactions with sensory neurons while providing a possible approach for treating itch-related diseases.
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Mg and the microbiome: A liver-protective duo Cell Host Microbe (IF 30.3) Pub Date : 2024-01-10 Jamie O. Yang, Tien S. Dong
Acute liver failure continues to carry high morbidity and mortality with limited therapeutic options. In this issue of Cell Host & Microbe, Li et al. demonstrate that oral magnesium can protect against acetaminophen-induced liver injury through alterations in the microbiome.
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“Messenger RNA just entered the chat”: The next layer of cross-kingdom RNA transfer Cell Host Microbe (IF 30.3) Pub Date : 2024-01-10 Alessa Ruf, Silke Robatzek
Infectious fungi send small RNAs into plant cells to enhance their virulence by silencing defense-related genes. In this issue of Cell Host & Microbe, Wang and colleagues show that full-length messenger RNA is transported in vesicles from plants to fungi, becoming translated by fungal ribosomes and reducing fungal pathogenicity.
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The gut microbiome as a guidepost for infection risk in liver transplantation Cell Host Microbe (IF 30.3) Pub Date : 2024-01-10 Angelica T. Vieira, Thomas F. Baumert
In this issue, Lehmann et al. addresses the high infection risk in liver transplantation by examining the gut microbiome in a patient cohort. By uncovering a predictive role of the microbiome for the clinical course, the study unravels the gut microbiome as a guidepost for infection risk in liver transplantation.
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Navigating the B vitamins: Dietary diversity, microbial synthesis, and human health Cell Host Microbe (IF 30.3) Pub Date : 2024-01-10 Yudie Yang, Yize Ke, Xinyan Liu, Zhidong Zhang, Rongji Zhang, Fang Tian, Luqian Zhi, Guoping Zhao, Bomin Lv, Sha Hua, Hao Wu
B vitamins are intricately involved in various physiological processes vital for health. Their significance is complicated by the heterogeneous landscape of B vitamin distribution in diets and the contributions of the gut microbiota. Here, we delve into the impact of these factors on B vitamins and introduce strategies, with a focus on microbiota-based therapeutic options, to enhance their availability
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Persistent Salmonella infections in humans are associated with mutations in the BarA/SirA regulatory pathway Cell Host Microbe (IF 30.3) Pub Date : 2024-01-10 Alexandra Grote, Bar Piscon, Abigail L. Manson, Boaz Adani, Helit Cohen, Jonathan Livny, Ashlee M. Earl, Ohad Gal-Mor
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Precision microbial intervention improves social behavior but not autism severity: A pilot double-blind randomized placebo-controlled trial Cell Host Microbe (IF 30.3) Pub Date : 2023-12-18 Luigi Mazzone, Sean W. Dooling, Elisabetta Volpe, Mirko Uljarević, Jillian L. Waters, Andrea Sabatini, Lucrezia Arturi, Roberta Abate, Assia Riccioni, Martina Siracusano, Marcela Pereira, Lars Engstrand, Fernanda Cristofori, Domenico Adduce, Ruggiero Francavilla, Mauro Costa-Mattioli, Antonio Y. Hardan
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tHIS way to cognitive development Cell Host Microbe (IF 30.3) Pub Date : 2023-12-13 Sylvie Rabot
The effect of the microbiota-gut-brain axis on cognitive development in infancy is increasingly being scrutinized. In this issue of Cell Host & Microbe, Cerdó, Ruiz, and colleagues skillfully combine clinical and preclinical analyses, including a fecal transplantation experiment, to reveal associations between microbiota composition, cognitive scores, and histidine metabolism.
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Fiber-deficient diets reprogram the microbiota Cell Host Microbe (IF 30.3) Pub Date : 2023-12-13 Bradley G. Fitzgerald, Matthew T. Sorbara
Exclusive enteral nutrition, a diet lacking fiber, is used to treat pediatric Crohn’s disease. In this issue of Cell Host & Microbe, Kuffa et al. find that a fiber-deficient diet thins the mucus layer and alters microbial cross-feeding, causing pro-inflammatory Mucispirillum to move away from the epithelium, which ameliorates colitis.
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It takes a plant village to raise a microbiome Cell Host Microbe (IF 30.3) Pub Date : 2023-12-13 Melissa Y. Chen, Cara H. Haney
In this issue of Cell Host and Microbe, Meyer et al. explore the effects of host history on the inheritance of the plant microbiome. They find that transmission from the same plant species resulted in microbiota specialization, while transmission from a different species resulted in host generalism.
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Bacterial antigens unleash tumor-targeting immunity Cell Host Microbe (IF 30.3) Pub Date : 2023-12-13 Nina Boeck, Zlatko Trajanoski, Lorenzo Galluzzi
The composition of the gut microbiome has been shown to influence disease outcome in patients with colorectal cancer (CRC). In a recent Nature Biotechnology article, Wang et al. demonstrate that killing CRC-associated bacteria with a liposomal antibiotic elicits CRC-targeting immune responses of therapeutic relevance as a consequence of epitope mimicry.
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“AHR-ming” host defense against cryptosporidiosis Cell Host Microbe (IF 30.3) Pub Date : 2023-12-13 Jojo Reyes, George S. Yap
Globally, cryptosporidiosis is a leading cause of childhood diarrheal disease and is a major risk factor for malnutrition and impairment of growth and cognitive development. In this issue of Cell Host & Microbe, Maradana et al. identify a target for dietary enhancement of innate immune defenses against cryptosporidiosis.
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Walking down the phosphorylation path to root immunity Cell Host Microbe (IF 30.3) Pub Date : 2023-12-13 Alberto P. Macho
Pathogen perception in plant roots is under-explored compared to that in shoots. In this issue of Cell Host & Microbe, Wang et al. characterize the phosphorylation-mediated signaling pathway that positively and negatively regulates plant resistance to bacterial wilt disease upon perception of a metabolite from the soil-borne vascular pathogen Ralstonia solanacearum.