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The role of Epstein-Barr virus in autoimmune and autoinflammatory diseases Crit. Rev. Microbiol. (IF 6.5) Pub Date : 2024-04-18 Abdul Hamid Borghol, Elio R. Bitar, Aya Hanna, Georges Naim, Elias A. Rahal
Epstein-Barr Virus (EBV), a dsDNA herpesvirus, is believed to play a significant role in exacerbating and potentially triggering autoimmune and autoinflammatory maladies. Around 90% of the world is...
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Addressing low-density malaria infections in India and other endemic part of the world—the opportune time? Crit. Rev. Microbiol. (IF 6.5) Pub Date : 2024-04-17 Loick P. Kojom Foko, Amit Moun, Vineeta Singh
Shifting from high- to low-malaria transmission accompanies a higher proportion of asymptomatic low-density malaria infections (LDMI). Currently, several endemic countries, such as India, are exper...
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The crosstalk between SUMOylation and immune system in host-pathogen interactions Crit. Rev. Microbiol. (IF 6.5) Pub Date : 2024-04-15 Gangli Zhu, Ni Tong, Yipeng Zhu, Lize Wang, Qirui Wang
Pathogens can not only cause infectious diseases, immune system diseases, and chronic diseases, but also serve as potential triggers or initiators for certain tumors. They directly or indirectly da...
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Periodontitis increases the risk of gastrointestinal dysfunction: an update on the plausible pathogenic molecuar mechanisms Crit. Rev. Microbiol. (IF 6.5) Pub Date : 2024-04-11 Sayantan Mukherjee, Aditi Chopra, Shaswata Karmakar, Subraya Giliyar Bhat
Periodontitis is an immuno-inflammatory disease of the soft tissues surrounding the teeth. Periodontitis is linked to many communicable and non-communicable diseases such as diabetes, cardiovascula...
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Ferroptosis, from the virus point of view: opportunities and challenges Crit. Rev. Microbiol. (IF 6.5) Pub Date : 2024-04-08 Xia Zhao, Yan Zhang, Bing Luo
Ferroptosis is a new type of cell death, which is mainly dependent on the formation and accumulation of reactive oxygen species and lipid peroxides mediated by iron. It is distinct from other forms...
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The implication of microbiome in lungs cancer: mechanisms and strategies of cancer growth, diagnosis and therapy Crit. Rev. Microbiol. (IF 6.5) Pub Date : 2024-03-31 Yasmin Bano, Abhinav Shrivastava, Piyush Shukla, Anis Ahmad Chaudhary, Salah-Ud-Din Khan, Shahanavaj Khan
Available evidence illustrates that microbiome is a promising target for the study of growth, diagnosis and therapy of various types of cancer. Lung cancer is a leading cause of cancer death worldw...
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Botanicals as promising antimicrobial agents for enhancing oral health: a comprehensive review Crit. Rev. Microbiol. (IF 6.5) Pub Date : 2024-03-28 Ekta Narwal, Jairam Choudhary, Manoj Kumar, Ryszard Amarowicz, Sunil Kumar, Radha, Deepak Chandran, Sangram Dhumal, Surinder Singh, Marisennayya Senapathy, Sureshkumar Rajalingam, Muthamilselvan Muthukumar, Mohamed Mekhemar
The mouth houses the second largest diversity of microorganisms in the body, harboring more than 700 bacterial species colonizing the soft mucosa and hard tooth surfaces. Microbes are the cause of ...
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Correction Crit. Rev. Microbiol. (IF 6.5) Pub Date : 2024-03-20
Published in Critical Reviews in Microbiology (Ahead of Print, 2024)
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Evaluation of the antifungal effect of plant extracts on oral Candidaspp. – a critical methodological analysis of the last decade Crit. Rev. Microbiol. (IF 6.5) Pub Date : 2024-03-18 M. Maziere, J. C. Andrade, P. Rompante, C. F. Rodrigues
In 2022, the World Health Organization published a report encouraging researchers to focus on Candida spp. to strengthen the global response to fungal oral infections and antifungal resistance. In ...
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The role and challenges of regulating endometrial microbiome in uterine health and diseases Crit. Rev. Microbiol. (IF 6.5) Pub Date : 2024-03-15 Chongshan Yuan, Kunyu Xie, Lianjun Feng, Shouyang Gao, Lifu Cai
The uterine environment provides necessary conditions for the existence of endometrial microbiota, which in turn plays an important role in maintaining the homeostasis of the uterine environment. T...
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Activation of the lysosomal damage response and selective autophagy: the coordinated actions of galectins, TRIM proteins, and CGAS-STING1 in providing immunity against Mycobacterium tuberculosis Crit. Rev. Microbiol. (IF 6.5) Pub Date : 2024-03-12 Asrar Ahmad Malik, Mohd Shariq, Javaid Ahmad Sheikh, Sheeba Zarin, Yashika Ahuja, Haleema Fayaz, Anwar Alam, Nasreen Z. Ehtesham, Seyed E. Hasnain
Autophagy is a crucial immune defense mechanism that controls the survival and pathogenesis of M. tb by maintaining cell physiology during stress and pathogen attack. The E3-Ub ligases (PRKN, SMURF...
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Vibrio cholerae virulence and its suppression through the quorum-sensing system Crit. Rev. Microbiol. (IF 6.5) Pub Date : 2024-03-05 Anusree Sajeevan, Thandavarayan Ramamurthy, Adline Princy Solomon
Vibrio cholerae is a cholera-causing pathogen known to instigate severe contagious diarrhea that affects millions globally. Survival of vibrios depend on a combination of multicellular responses an...
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Current developments and prospects of the antibiotic delivery systems Crit. Rev. Microbiol. (IF 6.5) Pub Date : 2024-02-29 Kusum Kharga, Shubhang Jha, Tanvi Vishwakarma, Lokender Kumar
Antibiotics have remained the cornerstone for the treatment of bacterial infections ever since their discovery in the twentieth century. The uproar over antibiotic resistance among bacteria arising...
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Peeling off the layers from microbial dark matter (MDM): recent advances, future challenges, and opportunities Crit. Rev. Microbiol. (IF 6.5) Pub Date : 2024-02-22 Sajid Iqbal, Farida Begum, Ihsan Ullah, Nasir Jalal, Peter Shaw
Microbes represent the most common organisms on Earth; however, less than 2% of microbial species in the environment can undergo cultivation for study under laboratory conditions, and the rest of t...
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Water and mosquitoes as key components of the infective cycle of Francisella tularensis in Europe: a review Crit. Rev. Microbiol. (IF 6.5) Pub Date : 2024-02-23 Daniel Herrera-Rodríguez, Sara Jareño-Moreno, Clara Buch-Cardona, François Mougeot, Juan José Luque-Larena, Dolors Vidal
Francisella tularensis is the pathogen of tularemia, a zoonotic disease that have a broad range of hosts. Its epidemiology is related to aquatic environments, particularly in the subspecies holarct...
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Antibiotic resistance: a global crisis, problems and solutions Crit. Rev. Microbiol. (IF 6.5) Pub Date : 2024-02-21 Rupesh Aggarwal, Pooja Mahajan, Sameeksha Pandiya, Aayushi Bajaj, Shailendra Kumar Verma, Puja Yadav, Arun S. Kharat, Asad Ullah Khan, Meenakshi Dua, Atul Kumar Johri
Healthy state is priority in today’s world which can be achieved using effective medicines. But due to overuse and misuse of antibiotics, a menace of resistance has increased in pathogenic microbes...
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Tumor-targeting bacteria as immune stimulants – the future of cancer immunotherapy? Crit. Rev. Microbiol. (IF 6.5) Pub Date : 2024-02-12 Alexandra M. Mowday, Jella M. van de Laak, Zhe Fu, Kimiora L. Henare, Ludwig Dubois, Philippe Lambin, Jan Theys, Adam V. Patterson
Cancer immunotherapies have been widely hailed as a breakthrough for cancer treatment in the last decade, epitomized by the unprecedented results observed with checkpoint blockade. Even so, only a ...
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Insights into the molecular mechanisms of H. pylori-associated B-cell lymphoma Crit. Rev. Microbiol. (IF 6.5) Pub Date : 2024-01-30 Kritika Malik, Prashant Kodgire
Cancer research has extensively explored various factors contributing to cancer development, including chemicals, drugs, smoking, and obesity. However, the role of bacterial infections in cancer in...
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Review on computer-assisted biosynthetic capacities elucidation to assess metabolic interactions and communication within microbial communities Crit. Rev. Microbiol. (IF 6.5) Pub Date : 2024-01-25 Mahnoor Zulfiqar, Vinay Singh, Christoph Steinbeck, Maria Sorokina
Microbial communities thrive through interactions and communication, which are challenging to study as most microorganisms are not cultivable. To address this challenge, researchers focus on the ex...
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Activation of host nucleic acid sensors by Mycobacterium: good for us or good for them? Crit. Rev. Microbiol. (IF 6.5) Pub Date : 2023-12-28 Jeffrey S. Schorey, Joseph Vecchio, William R. McManus, Joshua Ongalo, Kylie Webber
Although the importance of deoxyribonucleic acid (DNA) and ribonucleic acid (RNA) sensors in controlling viral infection is well established, their role in promoting an effective immune response to...
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Group A Streptococcus adaptation to diverse niches: lessons from transcriptomic studies Crit. Rev. Microbiol. (IF 6.5) Pub Date : 2023-12-23 Lionel Schiavolin, Geoffrey Deneubourg, Jenny Steinmetz, Pierre R. Smeesters, Anne Botteaux
Group A Streptococcus (GAS) is a major human pathogen, causing diseases ranging from mild superficial infections of the skin and pharyngeal epithelium to severe systemic and invasive diseases. More...
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A comprehensive guide on screening and selection of a suitable AMP against biofilm-forming bacteria Crit. Rev. Microbiol. (IF 6.5) Pub Date : 2023-12-15 Ananya Anurag Anand, Ayush Amod, Sarfraz Anwar, Amaresh Kumar Sahoo, Gautam Sethi, Sintu Kumar Samanta
Lately, antimicrobial resistance (AMR) is increasing at an exponential rate making it important to search alternatives to antibiotics in order to combat multi-drug resistant (MDR) bacterial infecti...
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Exploring microbial worlds: a review of whole genome sequencing and its application in characterizing the microbial communities Crit. Rev. Microbiol. (IF 6.5) Pub Date : 2023-11-25 Suleiman Aminu, AbdulAziz Ascandari, Meriem Laamarti, Nour El Houda Safdi, Achraf El Allali, Rachid Daoud
The classical microbiology techniques have inherent limitations in unraveling the complexity of microbial communities, necessitating the pivotal role of sequencing in studying the diversity of micr...
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Emerging strategies to target virulence in Pseudomonas aeruginosa respiratory infections Crit. Rev. Microbiol. (IF 6.5) Pub Date : 2023-11-24 Tegan M. Hibbert, Marvin Whiteley, Stephen A. Renshaw, Daniel R. Neill, Joanne L. Fothergill
Pseudomonas aeruginosa is an opportunistic pathogen that is responsible for infections in people living with chronic respiratory conditions, such as cystic fibrosis (CF) and non-CF bronchiectasis (...
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Natural and synthetic molecules with potential to enhance biofilm formation and virulence properties in Pseudomonas aeruginosa Crit. Rev. Microbiol. (IF 6.5) Pub Date : 2023-11-15 Geum-Jae Jeong, Fazlurrahman Khan, Nazia Tabassum, Young-Mog Kim
Pseudomonas aeruginosa can efficiently adapt to changing environmental conditions due to its ubiquitous nature, intrinsic/acquired/adaptive resistance mechanisms, high metabolic versatility, and th...
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Modulation of endoplasmic reticulum stress response pathways by respiratory viruses Crit. Rev. Microbiol. (IF 6.5) Pub Date : 2023-11-07 Kyle L. Macauslane, Cassandra L. Pegg, Kirsty R. Short, Benjamin L. Schulz
Acute respiratory infections (ARIs) are amongst the leading causes of death and disability, and the greatest burden of disease impacts children, pregnant women, and the elderly. Respiratory viruses...
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Ex vivo challenge models for infectious diseases Crit. Rev. Microbiol. (IF 6.5) Pub Date : 2023-11-01 Bhavna Gowan Gordhan, Dale Liebenberg, Gabriella Scarlatti, Carolina Herrera, Francesca Chiodi, Neil Martinson, Julie Fox, Bavesh Davandra Kana
Traditionally, molecular mechanisms of pathogenesis for infectious agents were studied in cell culture or animal models but have limitations on the extent to which the resulting data reflect natura...
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Microparticles and nanoparticles-based approaches to improve oral treatment of Helicobacter pylori infection Crit. Rev. Microbiol. (IF 6.5) Pub Date : 2023-10-28 Jessyca Aparecida Paes Dutra, Suzana Gonçalves Carvalho, Aline Soares de Oliveira, Jéssica Raquel Borges Monteiro, Jéssica Rodrigues Pereira de Oliveira Borlot, Marcela Tavares Luiz, Tais Maria Bauab, Rodrigo Rezende Kitagawa, Marlus Chorilli
Helicobacter pylori is a gram-negative, spiral-shaped, flagellated bacterium that colonizes the stomach of half the world’s population. Helicobacter pylori infection causes pathologies of varying s...
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The potential for bacteriophages and prophage elements in fighting and preventing the gonorrhea Crit. Rev. Microbiol. (IF 6.5) Pub Date : 2023-10-28 Monika Adamczyk-Popławska, Piotr Golec, Andrzej Piekarowicz, Agnieszka Kwiatek
Bacteriophages are the most numerous entities on earth and are found everywhere their bacterial hosts live. As natural bacteria killers, phages are extensively investigated as a potential cure for ...
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Current types of staphylococcal cassette chromosome mec (SCCmec) in clinically relevant coagulase-negative staphylococcal (CoNS) species Crit. Rev. Microbiol. (IF 6.5) Pub Date : 2023-10-26 Mariola Wolska-Gębarzewska, Jacek Międzobrodzki, Maja Kosecka-Strojek
Coagulase-negative staphylococci (CoNS) colonize human skin and mucosal membranes, which is why they are considered harmless commensal bacteria. Two species, Staphylococcus epidermidis and Staphylo...
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Advances in the applications of Bacteriophages and phage products against food-contaminating bacteria Crit. Rev. Microbiol. (IF 6.5) Pub Date : 2023-10-20 Suja E, Sathyanarayana N. Gummadi
Food-contaminating bacteria pose a threat to food safety and the economy by causing foodborne illnesses and spoilage. Bacteriophages, a group of viruses that infect only bacteria, have the potentia...
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Bile acid and its bidirectional interactions with gut microbiota: a review Crit. Rev. Microbiol. (IF 6.5) Pub Date : 2023-09-27 Shuqi He, Lanxin Li, Yingning Yao, Jinhan Su, Suzhen Lei, Yi Zhang, Hongliang Zeng
Bile acids (BAs) are an important metabolite produced by cholesterol catabolism. It serves important roles in glucose and lipid metabolism and host-microbe interaction. Recent research has shown th...
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Probiotics for pancreatic β-cell function: from possible mechanism of action to assessment of effectiveness Crit. Rev. Microbiol. (IF 6.5) Pub Date : 2023-09-13 Nazarii Kobyliak, Maria Khomenko, Tetyana Falalyeyeva, Alexandra Fedchenko, Oleksii Savchuk, Yuliya Tseyslyer, Liudmyla Ostapchenko
Abstract Type 2 diabetes (T2D) is a metabolic disease characterized by chronic hyperglycemia because of insulin resistance (IR) and\or pancreatic β-cell dysfunction. Last century research showed that gut microbiota has a direct effect on metabolism and metabolic diseases. New studies into the human microbiome and its connection with the host is making it possible to develop new therapies for a wide
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Mechanisms underlying the effects, and clinical applications, of oral microbiota in lung cancer: current challenges and prospects Crit. Rev. Microbiol. (IF 6.5) Pub Date : 2023-09-11 Qiong Ma, Xueke Li, Hua Jiang, Xi Fu, Liting You, Fengming You, Yifeng Ren
Abstract The oral cavity contains a site-specific microbiota that interacts with host cells to regulate many physiological processes in the human body. Emerging evidence has suggested that changes in the oral microbiota can increase the risk of lung cancer (LC), and the oral microbiota is also altered in patients with LC. Human and animal studies have shown that oral microecological disorders and/or
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Transformation of colitis and colorectal cancer: a tale of gut microbiota Crit. Rev. Microbiol. (IF 6.5) Pub Date : 2023-09-06 Kai Xia, Renyuan Gao, Lin Li, Xiaocai Wu, Tianqi Wu, Yu Ruan, Lu Yin, Chunqiu Chen
Abstract Intestinal inflammation modifies host physiology to promote the occurrence of colorectal cancer (CRC), as seen in colitis-associated CRC. Gut microbiota is crucial in cancer progression, primarily by inducing intestinal chronic inflammatory microenvironment, leading to DNA damage, chromosomal mutation, and alterations in specific metabolite production. Therefore, there is an increasing interest
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LysR-type transcriptional regulators: state of the art Crit. Rev. Microbiol. (IF 6.5) Pub Date : 2023-08-27 S. Mayo-Pérez, Y. Gama-Martínez, S. Dávila, N. Rivera, I. Hernández-Lucas
Abstract The LysR-type transcriptional regulators (LTTRs) are DNA-binding proteins present in bacteria, archaea, and in algae. Knowledge about their distribution, abundance, evolution, structural organization, transcriptional regulation, fundamental roles in free life, pathogenesis, and bacteria–plant interaction has been generated. This review focuses on these aspects and provides a current picture
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A comprehensive review of Bifidobacterium spp: as a probiotic, application in the food and therapeutic, and forthcoming trends Crit. Rev. Microbiol. (IF 6.5) Pub Date : 2023-08-08 Lejaniya Abdul Kalam Saleena, Sui Kiat Chang, Khanom Simarani, Kantha Deivi Arunachalam, Rarinthorn Thammakulkrajang, Yu Hsuan How, Liew Phing Pui
Abstract Recently, more consumers are interested in purchasing probiotic food and beverage products that may improve their immune health. The market for functional foods and beverages that include Bifidobacterium is expanding because of their potential uses in both food and therapeutic applications. However, maintaining Bifidobacterium’s viability during food processing and storage remains a challenge
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Non-antibiotic compounds associated with humans and the environment can promote horizontal transfer of antimicrobial resistance genes Crit. Rev. Microbiol. (IF 6.5) Pub Date : 2023-07-18 Ilyas Alav, Michelle M. C. Buckner
Abstract Horizontal gene transfer plays a key role in the global dissemination of antimicrobial resistance (AMR). AMR genes are often carried on self-transmissible plasmids, which are shared amongst bacteria primarily by conjugation. Antibiotic use has been a well-established driver of the emergence and spread of AMR. However, the impact of commonly used non-antibiotic compounds and environmental pollutants
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Type IV pili are involved in phenotypes associated with Clostridioides difficile pathogenesis Crit. Rev. Microbiol. (IF 6.5) Pub Date : 2023-07-15 Zirou Ouyang, Hanlin Zhao, Min Zhao, Yaxuan Yang, Jianhong Zhao
Abstract Clostridioides difficile is a Gram-positive, spore-forming, rod-shaped, obligate anaerobe that is the leading cause of antibiotic-associated diarrhea. Type IV pili (T4P) are elongated appendages on the surface of C. difficile that are polymerized from many pilin proteins. T4P play an important role in C. difficile adherence and particularly in its persistence in the host intestine. Recent
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Are anaerobic fungi crucial hidden players of microbiomes in anoxic environment? Crit. Rev. Microbiol. (IF 6.5) Pub Date : 2023-07-15 Enamul Hoque, Johannes Fritscher
Abstract Anaerobic fungi are known to migrate and establish a 3D network of biofilms (microbiomes) and live invisible in the rumen and terrestrial subsurface, deep-sea - marine, and anoxic environment. They deserve our attention to understand anoxic fungal ecology and functions and develop new products and solutions. Such fungi activate unique genes to produce various polysaccharidases deemed essential
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Molecular imaging of bacterial biofilms—a systematic review Crit. Rev. Microbiol. (IF 6.5) Pub Date : 2023-07-15 S. W. G. van Hoogstraten, C. Kuik, J. J. C. Arts, B. Cillero-Pastor
Abstract The formation of bacterial biofilms in the human body and on medical devices is a serious human health concern. Infections related to bacterial biofilms are often chronic and difficult to treat. Detailed information on biofilm formation and composition over time is essential for a fundamental understanding of the underlying mechanisms of biofilm formation and its response to anti-biofilm therapy
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Targeting the gut microbiota to alleviate chemotherapy-induced toxicity in cancer Crit. Rev. Microbiol. (IF 6.5) Pub Date : 2023-07-13 Yanin Xu, Haiyan Du, Yuchun Chen, Chong Ma, Qian Zhang, Hao Li, Zhiyong Xie, Yanjun Hong
Abstract Despite ongoing breakthroughs in novel anticancer therapies, chemotherapy remains a mainstream therapeutic modality in different types of cancer. Unfortunately, chemotherapy-related toxicity (CRT) often leads to dose limitation, and even results in treatment termination. Over the past few years, accumulating evidence has indicated that the gut microbiota is extensively engaged in various toxicities
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Interplay between lipid metabolism, lipid droplets and RNA virus replication Crit. Rev. Microbiol. (IF 6.5) Pub Date : 2023-06-22 Mónica A. Farías, Benjamín Diethelm-Varela, Alexis M. Kalergis, Pablo A. González
Abstract Lipids play essential roles in the cell as components of cellular membranes, signaling molecules, and energy storage sources. Lipid droplets are cellular organelles composed of neutral lipids, such as triglycerides and cholesterol esters, and are also considered as cellular energy reserves, yet new functions have been recently associated with these structures, such as regulators of oxidative
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Polyamine as a microenvironment factor in resistance to antibiotics Crit. Rev. Microbiol. (IF 6.5) Pub Date : 2023-06-20 Amrita C. Bhagwat, Sunil D. Saroj
Abstract One of the main issues in modern medicine is the decrease in the efficacy of antibiotic therapy against resistant microorganisms. The advent of antimicrobial resistance has added significantly to the impact of infectious diseases, in number of infections, as well as added healthcare costs. The development of antibiotic tolerance and resistance is influenced by a variety of environmental variables
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Towards the discovery of novel molecular clocks in Prokaryotes Crit. Rev. Microbiol. (IF 6.5) Pub Date : 2023-06-18 Augustin Géron, Johannes Werner, Ruddy Wattiez, Sabine Matallana-Surget
Abstract Diel cycle is of enormous biological importance as it imposes daily oscillation in environmental conditions, which temporally structures most ecosystems. Organisms developed biological time-keeping mechanisms – circadian clocks – that provide a significant fitness advantage over competitors by optimising the synchronisation of their biological activities. While circadian clocks are ubiquitous
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Outer membrane proteins and vesicles as promising vaccine candidates against Vibrio spp. infections Crit. Rev. Microbiol. (IF 6.5) Pub Date : 2023-06-05 Brijeshwar Singh, Surbhi Jaiswal, Prashant Kodgire
Abstract Indiscriminate use of antibiotics to treat bacterial infections has brought unmanageable antibiotic-resistant strains into existence. Vibrio spp. represents one such gram-negative enteric pathogenic group with more than 100 species, infecting humans and fish. The Vibrio spp. is demarcated into two groups, one that causes cholera and the other producing non-cholera or vibriosis infections.
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Applications of the phage display technology in molecular biology, biotechnology and medicine Crit. Rev. Microbiol. (IF 6.5) Pub Date : 2023-06-04 Karolina Pierzynowska, Joanna Morcinek-Orłowska, Lidia Gaffke, Weronika Jaroszewicz, Piotr M. Skowron, Grzegorz Węgrzyn
Abstract The phage display technology is based on the presentation of peptide sequences on the surface of virions of bacteriophages. Its development led to creation of sophisticated systems based on the possibility of the presentation of a huge variability of peptides, attached to one of proteins of bacteriophage capsids. The use of such systems allowed for achieving enormous advantages in the processes
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Acinetobacter baumannii subunit vaccines: recent progress and challenges Crit. Rev. Microbiol. (IF 6.5) Pub Date : 2023-05-21 Yi Teng Lau, Hock Siew Tan
Abstract Acinetobacter baumannii is a Gram-negative, opportunistic pathogen that causes nosocomial infection with a high mortality rate in immunocompromised individuals. With the frequent emergence of multidrug-resistant A. baumannii strains that have rapidly gained resistance to most antibiotics, an extensive search for an effective A. baumannii vaccine is ongoing. Over the decade, many subunit vaccine
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Oral host-microbe interactions investigated in 3D organotypic models Crit. Rev. Microbiol. (IF 6.5) Pub Date : 2023-05-11 Lin Shang, Dongmei Deng, Bastiaan P. Krom, Susan Gibbs
Abstract The oral cavity is inhabited by abundant microbes which continuously interact with the host and influence the host’s health. Such host-microbe interactions (HMI) are dynamic and complex processes involving e.g. oral tissues, microbial communities and saliva. Due to difficulties in mimicking the in vivo complexity, it is still unclear how exactly HMI influence the transition between healthy
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Evolutionary principles for modifying pathogen virulence Crit. Rev. Microbiol. (IF 6.5) Pub Date : 2023-05-05 Tom Fieldman
Abstract Current methods for combatting infectious diseases are largely limited to the prevention of infection, enhancing host immunity (via vaccination), and administration of small molecules to slow the growth of or kill pathogens (e.g. antimicrobials). Beyond efforts to deter the rise of antimicrobial resistance, little consideration is given to pathogen evolution. Natural selection will favor different
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Antibiotic resistance in the microbiota of periodontitis patients: an update of current findings Crit. Rev. Microbiol. (IF 6.5) Pub Date : 2023-05-04 Ethan Ng, John Rong Hao Tay, Sean Kuan Boey, Marja L Laine, Sašo Ivanovski, Chaminda Jayampath Seneviratne
Abstract Systemic antibiotics are an effective adjunct in the treatment of periodontitis, but their judicious use is necessary as antimicrobial resistance is a growing global concern. This review aims to explore the current understanding and insight related to antibiotic resistance in the subgingival microbiota of periodontitis patients. A search of MEDLINE (PubMed) was carried out from 1 January 2012
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Exploring halophilic environments as a source of new antibiotics Crit. Rev. Microbiol. (IF 6.5) Pub Date : 2023-04-20 Thomas P. Thompson, Brendan F. Gilmore
Abstract Microbial natural products from microbes in extreme environments, including haloarchaea, and halophilic bacteria, possess a huge capacity to produce novel antibiotics. Additionally, enhanced isolation techniques and improved tools for genomic mining have expanded the efficiencies in the antibiotic discovery process. This review article provides a detailed overview of known antimicrobial compounds
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Sensitive delivery systems and novel encapsulation technologies for live biotherapeutic products and probiotics Crit. Rev. Microbiol. (IF 6.5) Pub Date : 2023-04-19 Shuang Li, Yi-Xuan Zhang
Abstract Live biotherapeutic product (LBP), a type of biological product, holds promise for the prevention or treatment of metabolic disease and pathogenic infection. Probiotics are live microorganisms that improve the intestinal microbial balance and beneficially affect the health of the host when ingested in sufficient numbers. These biological products possess the advantages of inhibition of pathogens
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Long-Term effects of COVID-19: a review of current perspectives and mechanistic insights Crit. Rev. Microbiol. (IF 6.5) Pub Date : 2023-04-19 Christian Lenz, Mary P.E Slack, Kimberly M. Shea, Ralf René Reinert, Bülent N. Taysi, David L. Swerdlow
Abstract Although SARS-CoV-2, responsible for COVID-19, is primarily a respiratory infection, a broad spectrum of cardiac, pulmonary, neurologic, and metabolic complications can occur. More than 50 long-term symptoms of COVID-19 have been described, and as many as 80% of patients may develop ≥1 long-term symptom. To summarize current perspectives of long-term sequelae of COVID-19, we conducted a PubMed
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Engineered probiotics as live biotherapeutics for diagnosis and treatment of human diseases Crit. Rev. Microbiol. (IF 6.5) Pub Date : 2023-03-22 Jiao Meng, Shufan Liu, Xin Wu
Abstract The use of probiotics to regulate the intestinal microbiota to prevent and treat a large number of disorders and diseases has been an international research hotspot. Although conventional probiotics have a certain regulatory role in nutrient metabolism, inhibiting pathogens, inducing immune regulation, and maintaining intestinal epithelial barrier function, they are unable to treat certain
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The role of single and mixed biofilms in Clostridioides difficile infection and strategies for prevention and inhibition Crit. Rev. Microbiol. (IF 6.5) Pub Date : 2023-03-20 Saiwei Zhong, Jingpeng Yang, He Huang
Abstract Clostridioides difficile infection (CDI) is a serious disease with a high recurrence rate. The single and mixed biofilms formed by C. difficile in the gut contribute to the formation of recurrent CDI (rCDI). In parallel, other gut microbes influence the formation and development of C. difficile biofilms, also known as symbiotic biofilms. Interactions between members within the symbiotic biofilm
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Antimicrobial peptides as promising antibiotic adjuvants to combat drug-resistant pathogens Crit. Rev. Microbiol. (IF 6.5) Pub Date : 2023-03-08 Chen Chen, Jingru Shi, Dejuan Wang, Pan Kong, Zhiqiang Wang, Yuan Liu
Abstract The widespread antimicrobial resistance (AMR) calls for the development of new antimicrobial strategies. Antibiotic adjuvant rescues antibiotic activity and increases the life span of the antibiotics, representing a more productive, timely, and cost-effective strategy in fighting drug-resistant pathogens. Antimicrobial peptides (AMPs) from synthetic and natural sources are considered new-generation
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Bacteriophages: the dawn of a new era in periodontal microbiology? Crit. Rev. Microbiol. (IF 6.5) Pub Date : 2023-03-08 Shashikiran Shanmugasundaram, Namratha Nayak, Lakshmi Puzhankara, Madhurya N. Kedlaya, Anjale Rajagopal, Shaswata Karmakar
The oral microbiome, populated by a diverse range of species, plays a critical role in the initiation and progression of periodontal disease. The most dominant yet little-discussed players in the m...
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Phage-inspired strategies to combat antibacterial resistance Crit. Rev. Microbiol. (IF 6.5) Pub Date : 2023-02-21 Mianzhi Wang, Junxuan Zhang, Jingyi Wei, Lei Jiang, Li Jiang, Yongxue Sun, Zhenling Zeng, Zhiqiang Wang
Antimicrobial resistance (AMR) in clinically priority pathogensis now a major threat to public health worldwide. Phages are bacterial parasites that efficiently infect or kill specific strains and ...
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A comprehensive status update on modification of foley catheter to combat catheter-associated urinary tract infections and microbial biofilms Crit. Rev. Microbiol. (IF 6.5) Pub Date : 2023-01-18 Jatin Chadha, Navdisha Thakur, Sanjay Chhibber, Kusum Harjai
Present-day healthcare employs several types of invasive devices, including urinary catheters, to improve medical wellness, the clinical outcome of disease, and the quality of patient life. Among u...