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Towards a better understanding of Artemisia vulgaris: Botany, phytochemistry, pharmacological and biotechnological potential
Food Research International ( IF 8.1 ) Pub Date : 2018-03-29 , DOI: 10.1016/j.foodres.2018.03.072
Rambod Abiri , Abraão Lincoln Macedo Silva , Ludmilla Santos Silva de Mesquita , José Wilson Carvalho de Mesquita , Narges Atabaki , Eduardo Bezerra de Almeida , Noor Azmi Shaharuddin , Sonia Malik

Artemisia vulgaris is one of the important medicinal plant species of the genus Artemisia, which is usually known for its volatile oils. The genus Artemisia has become the subject of great interest due to its chemical and biological diversity as well as the discovery and isolation of promising anti-malarial drug artemisinin. A. vulgaris has a long history in treatment of human ailments by medicinal plants in various parts of the world. This medicinal plant possesses a broad spectrum of therapeutic properties including: anti-malarial, anti-inflammatory, anti-hypertensive, anti-oxidant, anti-tumoral, immunomodulatory, hepatoprotective, anti-spasmodic and anti-septic. These activities are mainly attributed to the presence of various classes of secondary metabolites, including flavonoids, sesquiterpene lactones, coumarins, acetylenes, phenolic acids, organic acids, mono- and sesquiterpenes. Studies related to A. vulgaris morphology, anatomy and phytochemistry has gained a significant interest for better understanding of production and accumulation of therapeutic compounds in this species. Recently, phytochemical and pharmacological investigations have corroborated the therapeutic potential of bioactive compounds of A. vulgaris. These findings provided further evidence for gaining deeper insight into the identification and isolation of novel compounds, which act as alternative sources of anti-malarial drugs in a cost-effective manner. Considering the rising demand and various medical applications of A. vulgaris, this review highlights the recent reports on the chemistry, biological activities and biotechnological interventions for controlled and continuous production of bioactive compounds from this plant species.



中文翻译:

更好地了解寻常蒿:植物学,植物化学,药理和生物技术潜力

蒿(Artemisia vulgaris)属(Artemisia)的重要药用植物之一,通常以其挥发油而闻名。属已经成为极大的兴趣的主题,由于其化学和生物多样性以及发现和有前途的抗疟疾药物青蒿素的隔离。寻常曲霉在世界各地使用药用植物治疗人类疾病的历史悠久。这种药用植物具有广泛的治疗特性,包括:抗疟疾,抗炎,抗高血压,抗氧化,抗肿瘤,免疫调节,保肝,抗痉挛和防腐。这些活性主要归因于各种次级代谢产物的存在,包括类黄酮,倍半萜烯内酯,香豆素,乙炔,酚酸,有机酸,单倍半萜和倍半萜。与寻常农杆菌有关的研究形态学,解剖学和植物化学对更好地了解该物种中治疗性化合物的产生和积累引起了极大的兴趣。近来,植物化学和药理学研究证实了寻常农杆菌的生物活性化合物的治疗潜力。这些发现为进一步深入鉴定和分离新型化合物提供了进一步的证据,这些新型化合物以具有成本效益的方式充当了抗疟药的替代来源。考虑到日益增长的需求和寻常A.的各种医疗应用,本综述重点介绍了有关从该植物物种控制和连续生产生物活性化合物的化学,生物活性和生物技术干预措施的最新报告。

更新日期:2018-03-29
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