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In vivo high-resolution human retinal imaging with wavefront-correctionless full-field OCT
Optica ( IF 10.4 ) Pub Date : 2018-04-02 , DOI: 10.1364/optica.5.000409
Peng Xiao , Viacheslav Mazlin , Kate Grieve , Jose-Alain Sahel , Mathias Fink , A. Claude Boccara

As the lateral resolution of full-field optical coherence tomography (FFOCT) with spatially incoherent illumination has been shown to be insensitive to aberrations, we demonstrate high-resolution en face FFOCT retinal imaging without wavefront correction in the human eye in vivo for the first time, to our knowledge. A combination of FFOCT with spectral-domain OCT (SDOCT) is applied for real-time matching of the optical path lengths (OPLs) of FFOCT. Through the real-time cross-sectional SDOCT images, the OPL of the FFOCT reference arm is matched with different retinal layers in the FFOCT sample arm. Thus, diffraction-limited FFOCT images of multiple retinal layers are acquired at both the near periphery and the fovea. The en face FFOCT retinal images reveal information about various structures, such as the nerve fiber orientation, the blood vessel distribution, and the photoreceptor mosaic.

中文翻译:

无需波前校正的全场OCT的体内高分辨率人视网膜成像

作为全视场的光学相干断层扫描(FFOCT)与空间非相干照明横向分辨率已被证明是不敏感的像差,我们证明高分辨率烯面FFOCT视网膜成像而不波前校正人眼体内首次,据我们所知。FFOCT与光谱域OCT(SDOCT)的组合可用于FFOCT的光路长度(OPL)的实时匹配。通过实时横截面SDOCT图像,FFOCT参考臂的OPL与FFOCT样本臂中的不同视网膜层相匹配。因此,在近周边和中央凹处都获得了多个视网膜层的衍射极限FFOCT图像。本恩面对 FFOCT视网膜图像显示有关各种结构的信息,例如神经纤维方向,血管分布和感光体镶嵌。
更新日期:2018-04-23
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