The complex process of pain control commonly involves the use of systemic analgesics; however, in many cases, a more potent and effective polypharmacological approach is needed to promote clinically significant improvement. Additionally, considering side effects caused by current painkillers, drug discovery is once more turning to nature as a source of more efficient therapeutic alternatives. In this context, arthropod venoms contain a vast array of bioactive substances that have evolved to selectively bind to specific pharmacological targets involved in the pain signaling pathway, playing an important role as pain activators or modulators, the latter serving as promising analgesic agents. The current review explores how the pain pathway works and surveys neuroactive compounds obtained from arthropods' toxins, which function as pain modulators through their interaction with specific ion channels and membrane receptors, emerging as promising candidates for drug design and development.

控制疼痛的复杂过程通常涉及全身镇痛药的使用。然而，在许多情况下，需要更有效和有效的多药理学方法来促进临床上的显着改善。另外，考虑到当前止痛药引起的副作用，药物发现再次转向自然界，成为更有效的治疗替代品的来源。在这种情况下，节肢动物毒液包含大量的生物活性物质，这些生物活性物质已经进化为选择性地与疼痛信号通路中涉及的特定药理学目标结合，起着疼痛激活剂或调节剂的重要作用，后者作为有希望的止痛剂。当前的评论探讨了疼痛途径的工作原理，并调查了从节肢动物毒素中获得的神经活性化合物，