Synthesis, structural characterisation and antiproliferative activity of a new fluorescent 4-amino-1,8-naphthalimide Tröger's base–Ru(ii)–curcumin organometallic conjugate†,Chemical Communications

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Synthesis, structural characterisation and antiproliferative activity of a new fluorescent 4-amino-1,8-naphthalimide Tröger's base–Ru(ii)–curcumin organometallic conjugate†
Chemical Communications ( IF 4.9 ) Pub Date : 2018-03-29 00:00:00 , DOI: 10.1039/c8cc01584h
Sankarasekaran Shanmugaraju _{1,

2,

3,

4,

5} , Bjørn la Cour Poulsen _{1,

2,

3,

4,

5} , Tobi Arisa _{1,

2,

3,

4,

5} , Deivasigamani Umadevi _{2,

3,

4,

5,

6} , Hannah L. Dalton _{1,

2,

3,

4,

5} , Chris S. Hawes _{1,

2,

3,

4,

5} , Sandra Estalayo-Adrián _{1,

2,

3,

4,

5} , Aramballi J. Savyasachi _{1,

2,

3,

4,

5} , Graeme W. Watson _{2,

3,

4,

5,

6} , D. Clive Williams _{2,

5,

7,

8,

9} , Thorfinnur Gunnlaugsson _{1,

2,

3,

4,

5}

Affiliation

The synthesis, photophysics and biological investigation of fluorescent 4-amino-1,8-naphthalimide Tröger's bases (TB-1–TB-3) and a new Tröger's base p-cymene–Ru(II)–curcumin organometallic conjugate (TB–Ru–Cur) are described; these compounds showed fast cellular uptake and displayed good luminescence and cytotoxicity against cervical cancer cells.

中文翻译：

新型荧光4-氨基-1,8-萘二甲酰亚胺特罗格碱-Ru（ii）-姜黄素有机金属共轭物的合成，结构表征和抗增殖活性†

荧光4-氨基-1,8-萘二甲酰亚胺Tröger碱（TB-1–TB-3）和新型Tröger碱p -cymene–Ru（II）–姜黄素有机金属共轭物（TB–Ru）的合成，光物理和生物学研究–Cur）进行了描述；这些化合物显示出快速的细胞摄取，并且对宫颈癌细胞显示出良好的发光和细胞毒性。

更新日期：2018-03-29

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