A modification of the Nenitzescu reaction was used to obtain Dronedarone from quinonimine 20 and 1,3-diketone 14 (R = CH₂CH₂CH₂NBu₂) in a two-stage process in almost 55% overall yield. Our results represent significant improvement over other state-of-the-art methods as no extra steps for the decoration of the benzofuran core are required.

中文翻译：

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决奈达隆的简短合成

Nenitzescu反应的一种修饰用于在两步法中从奎宁胺20和1,3-二酮14（R = CH ₂ CH ₂ CH ₂ NBu ₂）制得决奈达隆，总收率接近55％。我们的结果表明，与其他现有技术相比，已有显着改进，因为不需要额外的步骤来装饰苯并呋喃核。