Stem bromelain is a common available cysteine protease derived from pineapple (Ananas comosus L.). Bromelain finds widespread applications in several areas, such as medicine, health, food, and cosmetics, and its strong proteolytic activity supports its future application in many additional fields. However, most proteins and/or enzymes are fragile, leading to important considerations about increase storage and operational stability to enable their practical application. In this scenario, the use of nanoparticles to deliver proteins is increasing exponentially, given that these systems are capable of enhance active's stability, solubility and permeability, and decrease toxicity. In the pharmaceutical nanotechnology field, bromelain has played different roles and thus this paper aims to review the available literature for the use of nanoparticles and bromelain.

茎菠萝蛋白酶是一种常见的从菠萝中提取的半胱氨酸蛋白酶（菠萝（Ananas comosus L.））。菠萝蛋白酶在医学，保健，食品和化妆品等多个领域都有广泛的应用，其强大的蛋白水解活性支持其在许多其他领域的未来应用。然而，大多数蛋白质和/或酶是易碎的，导致关于增加储存和操作稳定性以使其能够实际应用的重要考虑。在这种情况下，使用纳米颗粒鉴于这些系统能够增强活性物质的稳定性，溶解性和通透性并降低毒性，因此传递蛋白质的能力呈指数级增长。在药物纳米技术领域，菠萝蛋白酶起着不同的作用，因此，本文旨在综述有关纳米颗粒和菠萝蛋白酶使用的现有文献。