Abstract A novel MXene-based nanocomposite (MXene/DNA/Pd/Pt) is synthesized and applied for the development of sensitive dopamine (DA) sensors. MXene nanosheets act as conductive matrix for Pd/Pt nanoparticles loading, and DNA is adsorbed on MXene surface through aromatic hydrophobic bases to induce the in-situ growth of PdNPs and Pd/Pt nanoparticles. The results reveal that DNA plays vital roles in the formation of the nanocomposites, which not only favors the dispersion of Ti3C2 nanosheets, but also facilitates the even growth of PdNPs and Pd/Pt nanoparticles. The deposition of Pd/Pt nanoparticles onto Ti3C2 nanosheets efficiently enhances the electrocatalytic activity of the nanocomposites towards DA. The constructed sensor exhibited linear amperometric response in the DA concentration range of 0.2–1000 μM with a lower detection limit of 30 nM (S/N = 3) and high selectivity against ascorbic acid (AA), uric acid (UA) and glucose (Glu). The successful determination of DA in human serum samples further verifies the potential application of the constructed sensors.

中文翻译：

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用于灵敏检测多巴胺的 MXene/DNA/Pd/Pt 纳米复合材料的合成

摘要 合成了一种新型的基于 MXene 的纳米复合材料 (MXene/DNA/Pd/Pt)，并将其用于开发灵敏的多巴胺 (DA) 传感器。MXene 纳米片作为负载 Pd/Pt 纳米粒子的导电基质，DNA 通过芳香族疏水碱基吸附在 MXene 表面，诱导 PdNPs 和 Pd/Pt 纳米粒子的原位生长。结果表明，DNA 在纳米复合材料的形成中起着至关重要的作用，不仅有利于 Ti3C2 纳米片的分散，而且有利于 PdNPs 和 Pd/Pt 纳米颗粒的均匀生长。Pd/Pt 纳米粒子在 Ti3C2 纳米片上的沉积有效地增强了纳米复合材料对 DA 的电催化活性。构建的传感器在 DA 浓度范围为 0 时表现出线性电流响应。2–1000 μM，检测下限为 30 nM (S/N = 3)，对抗坏血酸 (AA)、尿酸 (UA) 和葡萄糖 (Glu) 具有高选择性。人血清样品中DA的成功测定进一步验证了所构建传感器的潜在应用。