Diazomethane is an exceptionally versatile C1 building block in organic synthesis. However, reactions involving the use of diazomethane impose significant challenges for safe scale-up. This review aims to highlight the recent developments in processes and equipment concepts for the generation and consumption of diazomethane in continuous mode. We focus specifically on the continuous processes and equipment solutions that have, either individually or together, enabled the entire sequence consisting of synthesis of the diazomethane precursor, subsequent generation and purification of diazomethane, and the downstream reaction to achieve the target product. The discussions are performed mainly from an industrial perspective, and the processes are categorized by the capability to generate specific forms of diazomethane: as a neat gas, gas-diluted, or in organic solution. Lab processes and pilot processes are reviewed separately to demonstrate the options available to process diazomethane on different scales.

中文翻译：

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多步连续流系统中重氮甲烷的按需生成和消耗

重氮甲烷是有机合成中极其多用途的C1构建基块。但是，涉及使用重氮甲烷的反应对安全扩大规模提出了重大挑战。这篇综述旨在强调连续模式下重氮甲烷的产生和消耗过程和设备概念的最新发展。我们特别关注连续过程和设备解决方案，无论是单独还是一起使用，都使整个过程成为可能，包括重氮甲烷前体的合成，重氮甲烷的后续生成和纯化以及下游反应以实现目标产品。讨论主要从工业角度进行，其过程按产生特定形式的重氮甲烷的能力进行分类：作为纯净气体，气体稀释，或在有机溶液中。实验室过程和中试过程将分别进行审查，以展示可用于处理不同规模重氮甲烷的选项。