Two novel alkaloids, with an unprecedented carbon skeleton, pileamartines A (1) and B (2), together with the known alkaloid, julandine (I-a) were isolated from the alkaloidal fraction of Pilea aff. martinii leaves. Their structures were established by spectral data analysis, including MS and 2D NMR. The absolute configurations of 1 and 2 were suggested by comparison of their experimental and calculated electronic circular dichroism spectra. Compound 2 exhibited weak inhibitory activity against the α-glucosidase enzyme with an inhibition of 11% at a concentration of 200 µM. These compounds were not cytotoxic against several cancer cell lines even at a concentration of 150 µM.

从Pilea aff的生物碱部分中分离出了两个具有前所未有的碳骨架的新型生物碱pilemartinines A（1）和B（2），以及已知的生物碱julandine（Ia）。马丁尼叶。通过光谱数据分析（包括MS和2D NMR）确定了它们的结构。通过比较它们的实验和计算的电子圆二色性光谱，可以得出1和2的绝对构型。化合物2在200 µM的浓度下，对α-葡萄糖苷酶的抑制作用较弱，抑制率为11％。这些化合物即使在150 µM的浓度下也不会对几种癌细胞产生细胞毒性。