The conversion of a variety of well‐known test reactions, representing the key reactivity patterns of gold catalysis, were analyzed by GC and ¹H NMR. The study is focused on establishing of a strategical approach for the consideration of ligand influence and counter anion influence during the catalyst optimization including an industrial perspective. The study shows a dominance of the counter anion, a dominance which up to now has been neglected in most of the routine screenings. In addition, a drastic substrate‐dependency became obvious, even a marginal variation of the substrate already could strongly effect the catalytic activity and change the optimal counter anion or ligand. Based on the collected data a strategic concept for an efficient screening for a specific substrate is introduced, this concept can serve as an important guideline for catalyst optimization in homogeneous gold catalysis.

中文翻译：

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金催化抗衡阴离子的工业视角：就“配体效应”而言被低估了

的各种公知的试验反应，代表金催化中的关键反应性模式的转换中，通过GC分析¹1 H NMR。这项研究的重点是建立一种战略方法，以期在催化剂优化过程中考虑配体影响和抗衡阴离子的影响，包括从工业角度出发。这项研究显示了抗衡阴离子的优势，这一优势迄今为止在大多数常规筛选中都被忽略。此外，剧烈的底物依赖性变得明显，即使底物的微小变化也已经可以强烈影响催化活性并改变最佳的抗衡阴离子或配体。基于收集的数据，提出了一种有效筛选特定底物的战略概念，该概念可作为均相金催化中催化剂优化的重要指导。