当前位置: X-MOL 学术Food Chem. Toxicol. › 论文详情
Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)
Plant food allergy: Influence of chemicals on plant allergens
Food and Chemical Toxicology ( IF 4.3 ) Pub Date : 2018-03-24 , DOI: 10.1016/j.fct.2018.03.032
Youcef Shahali , Maryam Dadar

Plant-derived foods are the most common allergenic sources in adulthood. Owing to the rapidly increasing prevalence of plant food allergies in industrialized countries, the environmental factors are suspected to play a key role in development of allergic sensitization. The present article provides an overview of ways by which chemicals may influence the development and severity of allergic reactions to plant foods, with especial focus on plant allergens up-regulated under chemical stress. In plants, a substantial part of allergens have defense-related function and their expression is highly influenced by environmental stress and diseases. Pathogenesis-related proteins (PR) account for about 25% of plant food allergens and some are responsible for extensive cross-reactions between plant-derived foods, pollen and latex allergens. Chemicals released by anthropogenic sources such as agriculture, industrial activities and traffic-related air pollutants are potential drivers of the increasing sensitization to allergenic PRs by elevating their expression and by altering their immunogenicity through post-translational modifications. In addition, some orally-taken chemicals may act as immune adjuvants or directly trigger non-IgE mediated food allergy. Taken together, the current literature provides an overwhelming body of evidence supporting the fact that plant chemical exposure and chemicals in diet may enhance the allergenic properties of certain plant-derived foods.



中文翻译:

植物食物过敏:化学物质对植物过敏原的影响

植物性食物是成年后最常见的过敏源。由于工业化国家中植物性食物过敏症的迅速增加,人们怀疑环境因素在过敏性致敏的发展中起着关键作用。本文概述了化学物质可能影响植物食品过敏反应的发展和严重程度的方法,特别着重于在化学胁迫下上调的植物过敏原。在植物中,过敏原的很大一部分具有防御相关功能,其表达受环境压力和疾病的高度影响。致病相关蛋白(PR)约占植物食物过敏原的25%,其中一些与植物性食物,花粉和乳胶过敏原之间广泛的交叉反应有关。由农业,工业活动和与交通有关的空气污染物等人为来源释放的化学物质,通过提高其表达并通过翻译后修饰来改变其免疫原性,是引起对过敏性PR敏感性增加的潜在驱动力。此外,某些口服化学物质可能会充当免疫佐剂或直接引发非IgE介导的食物过敏。综上所述,目前的文献提供了大量的证据支持以下事实:植物性化学物质暴露和饮食中的化学物质可能会增强某些植物性食品的致敏特性。工业活动和与交通有关的空气污染物是潜在的驱动力,其通过提高其表达并通过翻译后修饰来改变其免疫原性,从而提高了对过敏性PR的敏感性。此外,一些口服化学物质可能会充当免疫佐剂或直接引发非IgE介导的食物过敏。综上所述,目前的文献提供了大量的证据支持以下事实:植物性化学物质暴露和饮食中的化学物质可能会增强某些植物性食品的致敏特性。工业活动和与交通有关的空气污染物是潜在的驱动力,其通过提高其表达并通过翻译后修饰来改变其免疫原性,从而提高了对过敏性PR的敏感性。此外,某些口服化学物质可能会充当免疫佐剂或直接引发非IgE介导的食物过敏。综上所述,当前的文献提供了大量的证据支持以下事实:植物性化学物质暴露和饮食中的化学物质可能会增强某些植物性食品的致敏特性。

更新日期:2018-03-24
down
wechat
bug