The viral gastroenteritis mediated by rotavirus remains a major health problem, causing significant infant morbidity and mortality, and health care costs worldwide. Diverse studies have indicated that some milk-derived fractions exhibit antirotaviral activity, associated to proteins such as immunoglobulins, lactoferrin, mucins, and lactadherin. Nevertheless, further studies are needed to enable greater understanding of the interaction mechanisms involving rotaviruses, host cells, and neutralizing agents. Our results demonstrate that bovine milk is a source of antirotaviral compounds against a wide range of strains. The neutralizing activity of milk fractions was found to be directed to the spike protein VP4, while the purified milk proteins inhibited through interaction with either VP4 and/or VP7. The present results highlight the huge potential of bovine milk components for their inclusion in functional foods to control rotavirus diarrhea.

由轮状病毒介导的病毒性肠胃炎仍然是一个主要的健康问题，导致婴儿的发病率和死亡率显着提高，并且在全球范围内增加了医疗费用。多样化的研究表明，一些牛奶衍生成分具有抗旋转病毒活性，与免疫球蛋白，乳铁蛋白，粘蛋白和乳黏附素等蛋白质有关。然而，需要进一步的研究以使人们更深入地了解轮状病毒，宿主细胞和中和剂的相互作用机制。我们的结果表明，牛乳是抗多种菌株的抗旋转病毒化合物的来源。发现牛奶级分的中和活性直接针对尖峰蛋白VP4，而纯化的牛奶蛋白则通过与VP4和/或VP7的相互作用而受到抑制。