Inflammation is a possible mediator of the relationship between metabolic syndrome (MetS) and osteoporosis. Palm tocotrienol, an anti-inflammatory agent, has been reported to exert beneficial effects for the treatment of MetS and osteoporosis individually. This study aimed to investigate the potential role of palm tocotrienol in preventing both MetS and bone loss in male rats via alleviating the inflammatory response. In this study, MetS was established in the rats fed with HCHF diet. This was accompanied by bone loss and elevated pro-inflammatory cytokine levels. Supplementation of palm tocotrienol improved MetS parameters, trabecular bone microstructure, bone strength, and reduced pro-inflammatory cytokines in the HCHF rats. A dose-dependent effect of palm tocotrienol was also observed in preventing MetS conditions. In conclusion, palm tocotrienol prevents both MetS and bone loss, possibly through its anti-inflammatory properties.

炎症可能是代谢综合症（MetS）与骨质疏松症之间关系的媒介。据报道，棕榈生育三烯酚是一种抗炎药，可单独治疗MetS和骨质疏松症，发挥有益作用。这项研究旨在探讨棕榈生育三烯酚通过减轻炎症反应在预防雄性大鼠MetS和骨质流失中的潜在作用。在这项研究中，在饲喂HCHF饮食的大鼠中建立了MetS。同时伴有骨质流失和促炎性细胞因子水平升高。补充棕榈生育三烯酚可改善HCHF大鼠的MetS参数，小梁骨微结构，骨强度并减少促炎细胞因子。在预防MetS疾病中也观察到了棕榈生育三烯酚的剂量依赖性作用。综上所述，