Dietary interventions have been proposed as an effective way to prevent age-related senescence. Here, we investigated the ability of kale juice (KJ) dietary supplementation to delay cognitive decline in the senescence-accelerated mouse prone 8 (SAMP8) mouse. SAMP8 mice were fed a diet containing 0.8% (w/w) KJ or a control diet for 16 weeks, and cognitive performance was examined using the Morris water maze. KJ administration improved spatial and leaning memory as well as suppressed levels of serum 8-hydroxy-2′-deoxyguanosine and brain malondialdehyde with respect to the control group. Furthermore, the KJ-fed group showed a significant increase in the gene transcription and protein expression of heat shock protein 70 (HSP70). 1-Sinapoyl-2-feruloyl gentiobiose was identified as one of the active components of KJ affecting HSP70 expression. These findings suggest that dietary kale supplementation can suppress cognitive decline and age-related oxidative damage through the activation of HSP70 in SAMP8 mice.

饮食干预已被提议作为预防与年龄有关的衰老的有效方法。在这里，我们调查了羽衣甘蓝汁（KJ）膳食补充剂延缓衰老加速小鼠倾向8（SAMP8）小鼠的认知能力下降的能力。用含有0.8％（w / w）KJ的饮食或对照饮食喂养SAMP8小鼠16周，并使用莫里斯水迷宫检查认知能力。相对于对照组，KJ给药改善了空间记忆和前倾记忆，并降低了血清8-羟基-2'-脱氧鸟苷和脑丙二醛的水平。此外，由KJ喂养的组显示出热休克蛋白70（HSP70）的基因转录和蛋白表达显着增加。1-Sinapoyl-2-feruloyl gentiobiose被确定为KJ影响HSP70表达的活性成分之一。