High salt diet is one of the most common causes for hypertension and myocardial damage. In this study, we evaluated the effects of high salt on hypertension and myocardial damage induced by millet enriched diets using male rats. 11 groups of Rats (12 per group), including high salt group (8% NaCl), 9 groups of high salt plus diverse brands of millet and the control group were treated for eight weeks. The blood pressure was measured weekly using the tail cuff method. The level of myocardium nitric oxide (NO) and angiotensin type 1 receptor (AT1) expression were also examined. The level of blood pressure and the expression of AT1 significantly increased, and the level of NO decreased in myocardium in high salt-treated group as compared to the control group. Millet treatments significantly attenuated the increase of blood pressure and oxidative damage; and regulated JAK-STAT signal pathway induced by high salt. The results suggest that millet-enriched diet has significant effects on the reduction of blood pressure and myocardial injury induced by high salt in male rats.

高盐饮食是高血压和心肌损害的最常见原因之一。在这项研究中，我们评估了高盐对雄性大鼠富含小米饮食引起的高血压和心肌损害的影响。11组大鼠（每组12只），包括高盐组（8％NaCl），9组高盐以及不同品牌的小米和对照组，进行了8周的治疗。使用尾套法每周测量一次血压。还检查了心肌一氧化氮（NO）和1型血管紧张素受体（AT1）的表达水平。与对照组相比，高盐处理组心肌的血压水平和AT1表达明显升高，而NO水平则下降。小米的治疗显着减轻了血压和氧化损伤的增加；并调节高盐诱导的JAK-STAT信号通路。结果表明，富含小米的饮食对降低雄性大鼠的血压和高盐引起的心肌损伤具有显著作用。