A novel synthetic approach was developed for the construction of the 1,2,3,4-tetrahydroisoquinoline framework possessing varied functions. The synthetic strategy was based on oxidative ring opening of some indene derivatives through their C=C bond, followed by double reductive amination of the dicarbonyl intermediates with various primary alkyl- or fluoroalkylamines.

中文翻译：

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1,2,3,4-四氢异喹啉衍生物的从头合成路线

开发了一种新的合成方法来构建具有多种功能的 1,2,3,4-四氢异喹啉骨架。合成策略基于一些茚衍生物通过它们的 C=C 键氧化开环，然后用各种伯烷基或氟烷基胺对二羰基中间体进行双还原胺化。