Physical energy-induced chemical surgery, a technique that induces antitumor effects by delivering a drug that exerts a therapeutic effect in response to physical energy and irradiating the diseased part with the corresponding physical energy, is a useful method to treat cancers with minimal systemic side effects. Among chemical surgery, photodynamic therapy (PDT) and neutron capture therapy (NCT) require a system that selectively delivers drugs to the diseased site. Although PDT and NCT have a similar concept, drug delivery systems (DDSs) for their purpose need different functions to solve the unique problems derived from the characteristics of respective physical energy. In this review, we will describe recent chemistry-based solutions including ours to overcome these challenges.

物理能诱导化学手术是一种通过提供响应物理能发挥治疗作用的药物并用相应的物理能照射患处来诱导抗肿瘤作用的技术，是治疗癌症且全身副作用最小的方法。 。在化学外科手术中，光动力疗法（PDT）和中子俘获疗法（NCT）需要一种将药物选择性地输送到患病部位的系统。尽管PDT和NCT具有相似的概念，但出于其目的，药物输送系统（DDS）需要不同的功能来解决源自各自物理能特性的独特问题。在这篇综述中，我们将介绍包括克服这些挑战在内的基于化学的最新解决方案。