Coumarin containing pyrazoline derivatives have been synthesized and tested as inhibitors of in vitro development of a chloroquine-sensitive (MRC-02) and chloroquine-resistant (RKL-2) strain of Plasmodium falciparum and in vivo Plasmodium berghei malaria. Docking study was also done on cysteine protease falcipain-2 which showed that the binding pose of C-14 molecule and epoxysuccinate, inhibitor of falcipain-2, binds in the similar pattern. The most active antimalarial compound was 3-(1-benzoyl-5-(4-flurophenyl)-4,5-dihydro-1H-pyrazol-3yl)-7-(diethyamino)-2H-chromen-2-one C-14, with an IC₅₀ of 4.21 µg/ml provided complete protection to the infected mice at 24 mg/kg X 4 days respectively.

含有吡唑啉衍生物的香豆素已被合成并经测试可作为恶性疟原虫和体内伯氏疟原虫疟原虫对氯喹敏感（MRC-02）和耐氯喹（RKL-2）菌株体外发育的抑制剂。还对半胱氨酸蛋白酶falcipain-2进行了对接研究，结果表明C-14分子与falcipain-2的抑制剂环氧琥珀酸酯的结合姿势相似。活性最高的抗疟化合物是3-（1-苯甲酰基-5-（4-氟苯基）-4,5-二氢-1H-吡唑-3yl）-7-（二乙氨基）-2H-铬-2-酮C-14，IC ₅₀为4.21 µg / ml，分别以24 mg / kg X 4天对感染的小鼠提供了完全的保护。