Here we report a retrospective cross-sectional study on Esophageal eosinophilia (EsEo) frequency in Brazil, for 2, 425 pediatric patients with symptoms associated with gastroesophageal diseases in 2012. EsEo is defined by ≥15 eosinophils per high power field (400x) and confirmed through histological analyses of esophageal biopsies. Overall, 126 patients had EsEo equating to a frequency of 5.2%. There was a significant difference between the endoscopic features of patients with EsEo, where 10.7% had erosive esophagitis, 3.0% had non-erosive esophagitis and 1% showed normal esophageal mucosa. According to the interaction of the variables in the Classification and Regression Tree Analysis, most patients diagnosed with EsEo were older males with erosive esophagitis. On the other hand, the lowest frequency of EsEo was found among younger females with non-erosive esophagitis/normal mucosa. Environmental conditions, including climate variation and changes, were observed in association with EsEo, supporting a potential role for environmental factors in its pathogenesis. There was an inverse correlation between the number of EsEo, rainfall and humidity. EsEo is a relatively frequent finding in the pediatric population of Brazil with symptoms of gastroesophageal diseases. Both clinical and histological examinations of patients are important for a reliable diagnostic of EsEo cases and to patient care.

中文翻译：

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巴西中部儿童食管嗜酸性粒细胞增多的频率。

在此，我们报告了一项关于 2012 年巴西食管嗜酸性粒细胞增多 (EsEo)​​ 频率的回顾性横断面研究，研究对象为 2, 425 名患有胃食管疾病相关症状的儿科患者。EsEo 的定义是每个高倍视野 (400x) ≥15 个嗜酸性粒细胞，并经证实通过食管活检的组织学分析。总体而言，126 名患者患有 EsEo，发生频率为 5.2%。EsEo患者的内镜特征存在显着差异，其中10.7%患有糜烂性食管炎，3.0%患有非糜烂性食管炎，1%显示正常食管黏膜。根据分类和回归树分析中变量的相互作用，大多数诊断为 EsEo 的患者是患有糜烂性食管炎的老年男性。另一方面，EsEo 发生频率最低的是患有非糜烂性食管炎/正常粘膜的年轻女性。观察到的环境条件，包括气候变化和变化，与 EsEo 相关，支持环境因素在其发病机制中的潜在作用。EsEo数量、降雨量和湿度之间存在负相关关系。EsEo 在巴西有胃食管疾病症状的儿科人群中相对常见。患者的临床和组织学检查对于 EsEo 病例的可靠诊断和患者护理都很重要。