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Associations between serum relaxin 2, aneurysm formation/size and severity of atherosclerosis: a preliminary prospective analysis.
Acta Pharmacologica Sinica ( IF 8.2 ) Pub Date : 2018-Jul-01 , DOI: 10.1038/aps.2018.8
Konstantinos Papoutsis , Alkistis Kapelouzou , Diamantis I Tsilimigras , Nikolaos Patelis , Georgios Kouvelos , Dimitrios Schizas , Ioannis Karavokyros , Sotirios Georgopoulos

Serum relaxin 2 (RL2) is a pleiotropic hormone that acts on various organs and systems, particularly the cardiovascular system. Although RL2 seems to upregulate the synthesis of nitric monoxide (NO) and matrix metalloproteinase (MMP)-2 and -9, current literature on its role in atherosclerosis and aneurysm formation is scarce. The aim of this study was to investigate the levels of serum RL2 in patients with an arterial aneurysm as well as in atherosclerotic patients, and correlate them with the severity of their related vascular disease. A total of 53 subjects were enrolled in this study: 37 patients were scheduled to undergo surgery: 21 patients for different forms of atherosclerotic disease (ATH), 16 patients for an arterial aneurysm (AA), 6 patients for undergoing temporal artery biopsy (TAB), and 10 healthy blood donors (HBD) served as the control groups. RL2 was measured using enzymelinked immunosorbent assay. RL2 was significantly higher in AA patients compared to ATH (P<0.01), TAB (P<0.001) and HBD (P<0.01). No significant difference was found between the ATH and TAB groups (P>0.05). In addition, ATH and AA patients were further subdivided based on the severity of their disease. Serum RL2 was progressively increased in patients with arterial aneurysms, showing a positive relationship with the size of the aneurysmatic dilatation. By contrast, the RL2 level was inversely related to the severity of the atherosclerotic disease. Studies with a larger cohort incorporating a consistent study population are warranted to verify our results and shed light on the mechanistic background of these processes.

中文翻译:

血清松弛素2,动脉瘤形成/大小与动脉粥样硬化严重程度之间的关联:初步的前瞻性分析。

血清松弛素2(RL2)是一种多效激素,作用于各种器官和系统,尤其是心血管系统。尽管RL2似乎上调了一氧化氮(NO)和基质金属蛋白酶(MMP)-2和-9的合成,但有关其在动脉粥样硬化和动脉瘤形成中作用的文献很少。这项研究的目的是调查动脉瘤患者以及动脉粥样硬化患者的血清RL2水平,并将其与相关血管疾病的严重程度相关联。共有53位受试者参与了这项研究:37位患者计划进行手术:21位不同形式的动脉粥样硬化性疾病(ATH)的患者,16位动脉瘤(AA)的患者,6位进行颞动脉活检(TAB)的患者),对照组为10名健康献血者(HBD)。使用酶联免疫吸附测定法测量RL2。与ATH(P <0.01),TAB(P <0.001)和HBD(P <0.01)相比,AA患者的RL2显着更高。ATH组和TAB组之间无显着性差异(P> 0.05)。此外,ATH和AA患者根据其疾病的严重程度进一步细分。动脉瘤患者的血清RL2逐渐增加,与动脉瘤扩张的大小呈正相关。相比之下,RL2水平与动脉粥样硬化疾病的严重程度成反比。我们需要对具有相同研究人群的较大人群进行研究,以验证我们的结果并阐明这些过程的机制背景。使用酶联免疫吸附测定法测量RL2。与ATH(P <0.01),TAB(P <0.001)和HBD(P <0.01)相比,AA患者的RL2显着更高。ATH组和TAB组之间无显着性差异(P> 0.05)。此外,ATH和AA患者根据疾病的严重程度进一步细分。动脉瘤患者的血清RL2逐渐增加,与动脉瘤扩张的大小呈正相关。相比之下,RL2水平与动脉粥样硬化疾病的严重程度成反比。我们需要对具有相同研究人群的较大人群进行研究,以验证我们的结果并阐明这些过程的机制背景。使用酶联免疫吸附测定法测量RL2。与ATH(P <0.01),TAB(P <0.001)和HBD(P <0.01)相比,AA患者的RL2显着更高。ATH组和TAB组之间无显着性差异(P> 0.05)。此外,ATH和AA患者根据其疾病的严重程度进一步细分。动脉瘤患者的血清RL2逐渐增加,与动脉瘤扩张的大小呈正相关。相比之下,RL2水平与动脉粥样硬化疾病的严重程度成反比。我们需要对具有相同研究人群的较大人群进行研究,以验证我们的结果并阐明这些过程的机制背景。与ATH(P <0.01),TAB(P <0.001)和HBD(P <0.01)相比,AA患者的RL2显着更高。ATH组和TAB组之间无显着性差异(P> 0.05)。此外,ATH和AA患者根据其疾病的严重程度进一步细分。动脉瘤患者的血清RL2逐渐增加,与动脉瘤扩张的大小呈正相关。相比之下,RL2水平与动脉粥样硬化疾病的严重程度成反比。我们需要对具有相同研究人群的较大人群进行研究,以验证我们的结果并阐明这些过程的机制背景。与ATH(P <0.01),TAB(P <0.001)和HBD(P <0.01)相比,AA患者的RL2显着更高。ATH组和TAB组之间无显着性差异(P> 0.05)。此外,ATH和AA患者根据其疾病的严重程度进一步细分。动脉瘤患者的血清RL2逐渐增加,与动脉瘤扩张的大小呈正相关。相比之下,RL2水平与动脉粥样硬化疾病的严重程度成反比。我们需要对具有相同研究人群的较大人群进行研究,以验证我们的结果并阐明这些过程的机制背景。此外,ATH和AA患者根据其疾病的严重程度进一步细分。动脉瘤患者的血清RL2逐渐增加,与动脉瘤扩张的大小呈正相关。相比之下,RL2水平与动脉粥样硬化疾病的严重程度成反比。我们需要对具有相同研究人群的较大人群进行研究,以验证我们的结果并阐明这些过程的机制背景。此外,ATH和AA患者根据其疾病的严重程度进一步细分。动脉瘤患者的血清RL2逐渐增加,与动脉瘤扩张的大小呈正相关。相比之下,RL2水平与动脉粥样硬化疾病的严重程度成反比。我们需要对具有相同研究人群的较大人群进行研究,以验证我们的结果并阐明这些过程的机制背景。
更新日期:2018-03-22
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