As the accumulation of microplastics (MPs) in the environment continues to rise, more concerns focus on the health risk of combined exposure to MPs and other contaminants. The aim of this study is to investigate the influences of MPs on the tissue-accumulation of cadmium (Cd) in zebrafish and explore the related chronic toxic effects induced by combined exposure of Cd and MPs. After co-exposure to MPs and Cd for 3 weeks, 20 and 200 μg/L MPs increased the accumulation of Cd in zebrafish livers (46% and 184%), guts (10% and 25%) and gills (9% and 46%). The Cd accumulation was gill > gut > liver. Comprehensive analyzes of biochemical biomarkers, histopathological observation and functional gene expression firstly demonstrated that the presence of MPs enhanced the toxicity of Cd on zebrafish and the combined exposure caused oxidative damage and inflammation in zebrafish tissues. Collectively, our results highlight the chronic effects of combined exposure to MPs and heavy metals.

随着环境中微塑料（MPs）的积累持续增加，更多的关注点集中在MPs和其他污染物的联合暴露对健康的危害上。本研究的目的是研究MPs对斑马鱼中镉（Cd）组织积累的影响，并探讨Cd和MPs联合暴露引起的相关慢性毒性作用。与MPs和Cd共同暴露3周后，20和200μg/ L MPs会增加斑马鱼肝脏（46％和184％），胆量（10％和25％）和g（9％和46）中Cd的积累％）。镉的积累是g>肠>肝脏。生化生物标志物的综合分析，组织病理学观察和功能基因表达首次证明，MPs的存在增强了Cd对斑马鱼的毒性，并且联合暴露引起斑马鱼组织中的氧化损伤和炎症。总的来说，我们的结果强调了MP和重金属联合暴露的长期影响。