The solid-form landscape of urea was explored using full interaction maps (FIMs) and data from the CSD to develop optimum protocols for synthesizing co-crystals of urea. As a result, 49 of the 60 attempted reactions produced new co-crystals, and the crystal structures of four of these are presented. Moreover, the goal of reducing the solubility and lowering the hygroscopicity of the parent compound was achieved, which in turn offers new opportunities for application as a slow-release fertilizer with limited hygroscopicity, thereby reducing many current problems of transport, handling, and storage of urea.

中文翻译：

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使用共结晶技术调节尿素固体形式的物理性能†

使用完全相互作用图（FIM）和来自CSD的数据探索了尿素的固态形态，以开发用于合成尿素共晶体的最佳方案。结果，在60个尝试的反应中，有49个产生了新的共晶体，并给出了其中四个的晶体结构。而且，达到了降低母体化合物的溶解度和降低其吸湿性的目的，这反过来又为用作吸湿性有限的缓释肥料提供了新的机会，从而减少了目前运输，处理和储存香根草的许多问题。尿素。