Reassessment of long circulation via monitoring of integral polymeric nanoparticles justifies a more accurate understanding†,Nanoscale Horizons

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Reassessment of long circulation via monitoring of integral polymeric nanoparticles justifies a more accurate understanding†
Nanoscale Horizons ( IF 9.7 ) Pub Date : 2018-03-22 00:00:00 , DOI: 10.1039/c8nh00010g
Haisheng He _{1,

2,

3,

4,

5} , Sifan Jiang _{5,

6,

7,

8} , Yunchang Xie _{1,

2,

3,

4,

5} , Yi Lu _{1,

2,

3,

4,

5} , Jianping Qi _{1,

2,

3,

4,

5} , Xiaochun Dong _{1,

2,

3,

4,

5} , Weili Zhao _{1,

2,

3,

4,

5} , Zongning Yin _{5,

6,

7,

8} , Wei Wu _{1,

2,

3,

4,

5}

Affiliation

Monitoring of payloads results in a biased perception of long circulation of nanoparticles. Instead, herein, the long-circulation effect was re-confirmed by monitoring integral nanoparticles, but circulation was not found to be as long as generally perceived. In contrast, disparate pharmacokinetics were obtained by monitoring a model drug, paclitaxel, highlighting the bias of the conventional protocol.

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