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Short communication: The effect of novel antiseptic compounds on umbilical cord healing and incidence of infection in dairy calves
Journal of Dairy Science ( IF 3.5 ) Pub Date : 2018-03-21
A.L. Fordyce, L.L. Timms, K.J. Stalder, H.D. Tyler

The goal of dipping the umbilical cord after birth in calves is to promote healing of the umbilical stump, prevent infection, and encourage the umbilical tissue to detach from the body. Treatment applied to the umbilical area is an important management step for preventing morbidity and mortality in calves. The objective of this study was to compare the effect of 4 umbilical dips on the healing rate, incidence of infection, and age at umbilical cord detachment using newborn Holstein heifer calves (n = 73). Calves were alternately assigned by birth order to 4 treatment groups: 7% iodine, a dry dip formulated using an antibacterial peptide (nisin) mixed with talc (3.105 g of nisin per 100 g of talcum powder on a weight per weight basis), liquid nisin (64 µg/mL), and 4% chlorhexidine mixed with alcohol in a 50:50 solution. Umbilical cords were dipped 30 min after birth. Before initial dipping, umbilical cord diameter (as an indicator of the rate of cord drying and healing rate) was determined using a digital caliper. The caliper measurements were repeated at 24 ± 1, 48 ± 1, and 72 ± 1 h (±standard deviation) of age and were continued daily until the umbilical cord healed and detached from the animal's body. Diagnosed umbilical infections were documented by veterinary staff based on a combination of clinical symptoms (redness, swelling, purulent discharge, painful response (flinch or kicking) to palpation of the umbilical stump) in addition to a lack of appetite and fever. Data were analyzed using MIXED model procedures with fixed effect of umbilical treatment. No treatment differences were noted between dips on the umbilical cord drying rate or days for umbilical cord to detach. Treatment effects were observed on incidence of umbilical infection (incidence of infection for calves across all treatments was 9.0%).



中文翻译:

简短交流:新型抗菌化合物对乳牛犊脐带愈合和感染发生率的影响

出生后将脐带浸入小牛的目的是促进脐带残端的愈合,防止感染,并鼓励脐带组织脱离人体。对脐带部位进行治疗是预防小牛发病和死亡的重要管理步骤。这项研究的目的是比较使用新生的荷斯坦小母牛犊牛(n = 73)比较4次脐带浸洗对脐带脱离的治愈率,感染发生率和年龄的影响。将小牛按出生顺序交替分配给4个治疗组:7%碘,使用抗菌肽(乳链菌肽)与滑石粉混合配制的干浸剂(每100克滑石粉按重量/重量计3.105克乳链菌肽),液体乳链菌肽(64微克/毫升)和4%的洗必泰与酒精在50:50的溶液中混合。出生后30分钟将脐带浸入。初次浸入之前,使用数字卡尺确定脐带直径(作为脐带干燥速度和愈合速度的指标)。在24±1、48±1和72±1小时(±标准偏差)的年龄重复进行卡尺测量,每天进行一次,直到脐带he愈并从动物体内脱离。除缺乏食欲和发烧外,兽医人员还根据临床症状(发红,肿胀,脓性分泌物,触诊脐残端的疼痛反应(退缩或脚踢))综合记录了诊断出的脐带感染。使用固定的脐带处理效果,使用MIXED模型程序分析数据。脐带干燥速率的下降或脐带分离的天数之间未发现治疗差异。观察到了脐带感染发生率的治疗效果(在所有治疗中小牛的感染发生率为9.0%)。

更新日期:2018-03-22
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