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Left-Sided Atrial Septal Pouch is a Risk Factor for Cryptogenic Stroke
Journal of the American Society of Echocardiography ( IF 6.5 ) Pub Date : 2018-03-21 , DOI: 10.1016/j.echo.2018.01.023
Mateusz K. Hołda , Agata Krawczyk-Ożóg , Mateusz Koziej , Danuta Sorysz , Jakub Hołda , Dariusz Dudek , Wiesława Klimek-Piotrowska

Background

The atrial septal pouch is an anatomic variant of the interatrial septum. The morphology of the left-sided septal pouch (LSSP) may favor blood stasis and predispose to thromboembolic events. The aim of this study was to determine the association between LSSP presence and cryptogenic stroke.

Methods

A total of 126 consecutive patients with cryptogenic stroke and 137 age-matched control patients without stroke were analyzed retrospectively. The presence and dimensions of LSSPs were assessed using transesophageal echocardiography.

Results

LSSP was present in 55.6% of patients with cryptogenic stroke and in 40.9% of those without stroke (P = .02). In univariate analysis, patients with LSSP were more likely to have cryptogenic stroke (odds ratio, 1.81; 95% CI, 1.11–2.95; P = .02). After adjusting for other risk factors using multiple logistic regression, the presence of an LSSP was found to be associated with an increased risk for cryptogenic stroke (odds ratio, 2.02; 95% CI, 1.19–3.41; P = .01). There were no statistically significant differences in size of the LSSP between patients with and those without stroke (P > .05).

Conclusions

There is an association between the presence of an LSSP and an increased risk for cryptogenic stroke. More attention should be paid to clinical evaluations of LSSPs.



中文翻译:

左心房间隔袋是隐源性卒中的危险因素

背景

房间隔袋是房间隔的解剖学变体。左侧中隔袋(LSSP)的形态可能有利于血瘀并且易发生血栓栓塞事件。这项研究的目的是确定LSSP的存在与隐源性中风之间的关联。

方法

回顾性分析了126例连续的隐源性卒中患者和137例年龄匹配的无卒中的对照患者。LSSPs的存在和大小通过经食道超声心动图评估。

结果

LSSP在有隐源性卒中的患者中占55.6%,在没有卒中的患者中占40.9%(P  = .02)。在单因素分析中,LSSP患者更有可能患有隐源性卒中(比值比为1.81; 95%CI为1.11-2.95;P  = .02)。使用多元逻辑回归对其他风险因素进行调整后,发现LSSP的存在与隐源性中风的风险增加相关(比值比为2.02; 95%CI为1.19-3.41;P  = 0.01)。有和没有中风的患者之间,LSSP的大小没有统计学上的显着差异(P  > .05)。

结论

LSSP的存在与隐源性中风的风险增加之间存在关联。应更加重视LSSP的临床评估。

更新日期:2018-03-21
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