Microbiological Research ( IF 6.7 ) Pub Date : 2018-03-19 , DOI: 10.1016/j.micres.2018.03.008 Mattia Pia Arena , Firas Elmastour , Famara Sane , Djamel Drider , Daniela Fiocco , Giuseppe Spano , Didier Hober
The enterovirus Coxsackievirus B4 (CV-B4) can infect different human tissues and provoke abnormal function or destruction of various organs and cells. Moreover, its infections have been linked to the onset of type 1 diabetes. Coxsackievirus B4 is classified as a “challenging virus”, due to the intense yet vain efforts to find effective prevention and therapeutic agents, especially within biological compounds. Lactobacillus plantarum is a lactic acid bacterium that is endowed with probiotic properties, and holds great potential for applications in medical and food industry sectors. Several compounds produced by this microorganism have been associated with various benefits including antimicrobial activity. In this work, we investigated the possible antiviral abilities of two Lb. plantarum strains and their derivatives against CV-B4. The different assays carried out (e.g. pre-incubation, competition and post-infection, using HEp-2 cells as human cell model) suggest that the tested microorganisms and their derivatives have an in vitro inhibiting activity against CV-B4. This is the first report showing the anti-CVB4 activity of Lb. plantarum strains and their derivatives.
中文翻译:
植物乳杆菌对柯萨奇病毒B4的抑制作用
肠病毒柯萨奇病毒B4(CV-B4)可以感染不同的人体组织,并引起各种器官和细胞的异常功能或破坏。此外,其感染与1型糖尿病的发作有关。柯萨奇病毒B4被归类为“具有挑战性的病毒”,原因是人们为寻找有效的预防和治疗剂而付出了巨大努力,但徒劳地努力,尤其是在生物化合物中。植物乳杆菌是一种具有益生菌特性的乳酸菌,在医疗和食品工业领域具有巨大的应用潜力。由这种微生物产生的几种化合物已经具有包括抗菌活性在内的各种益处。在这项工作中,我们调查了两个Lb可能的抗病毒能力。植物菌株及其衍生物抗CV-B4。进行的不同测定(例如,使用HEp-2细胞作为人类细胞模型进行的预培养,竞争和感染后)表明,被测微生物及其衍生物具有针对CV-B4的体外抑制活性。这是第一个显示Lb抗CVB4活性的报告。植物乳杆菌菌株及其衍生物。