The design of nanoparticulate systems which can perform multiple synergistic functions in cells with high specificity and selectivity is of great importance in applications. Here we combine recent advances in DNA-gold nanoparticle self-assembly and sensing to develop gold nanoparticle dimers that are able to perform multiplexed synergistic functions within a cellular environment. These dimers can sense two mRNA targets and simultaneously or independently deliver one or two DNA-intercalating anticancer drugs (doxorubicin and mitoxantrone) in live cells. Our study focuses on the design of sophisticated nanoparticle assemblies with multiple and synergistic functions that have the potential to advance sensing and drug delivery in cells.

中文翻译：

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使用DNA-金纳米粒子二聚体的多重mRNA传感和组合靶向药物递送。

可以在细胞中以高特异性和选择性执行多种协同功能的纳米颗粒系统的设计在应用中非常重要。在这里，我们结合了DNA-金纳米粒子自组装和传感技术的最新进展，以开发能够在细胞环境中执行多重协同功能的金纳米粒子二聚体。这些二聚体可以感知两个mRNA靶点，并在活细胞中同时或独立递送一种或两种可插入DNA的抗癌药物（阿霉素和米托蒽醌）。我们的研究重点在于具有多种协同功能的复杂纳米颗粒组件的设计，这些组件具有促进细胞内传感和药物递送的潜力。