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Gestational Diabetes Mellitus: Does One Size Fit All? A Challenge to Uniform Worldwide Diagnostic Thresholds
Diabetes Care ( IF 16.2 ) Pub Date : 2018-07-01 , DOI: 10.2337/dc17-2393
H. David McIntyre 1, 2 , Dorte M. Jensen 3, 4, 5 , Richard C. Jensen 3, 6, 7 , Henriette B. Kyhl 8, 9 , Tina K. Jensen 6, 9, 10 , Dorte Glintborg 3, 5 , Marianne Andersen 3, 5
Affiliation  

OBJECTIVE To define the prevalence and pregnancy outcomes related to elevated fasting venous plasma glucose (FVPG) in a Danish pregnancy cohort.

RESEARCH DESIGN AND METHODS This was an observational cohort study including 1,516 women without gestational diabetes mellitus (GDM) by Danish criteria. FVPG measured at 28 weeks’ gestation was related to pregnancy outcomes.

RESULTS With use of the World Health Organization (WHO) 2013 threshold of FVPG ≥5.1 mmol/L, 40.1% of the cohort qualified as having GDM. There was no evidence of excess fetal growth, hypertension in pregnancy, or cesarean delivery in women with FVPG <5.6 mmol/L.

CONCLUSIONS The WHO 2013 FVPG threshold for GDM is unsuitable for Denmark. It inappropriately labels as having GDM an unmanageably large number of women who are at low absolute risk of pregnancy complications.



中文翻译:

妊娠糖尿病:一种尺寸适合所有人吗?全球统一诊断阈值的挑战

目的确定与丹麦妊娠队列中空腹静脉血浆葡萄糖(FVPG)升高有关的患病率和妊娠结局。

研究设计与方法这是一项观察性队列研究,根据丹麦的标准,包括1,516名无妊娠糖尿病(GDM)的妇女。妊娠28周时测得的FVPG与妊娠结局有关。

结果使用世界卫生组织(WHO)2013 FVPG阈值≥5.1mmol / L的队列,有40.1%的人符合GDM的条件。没有证据表明FVPG <5.6 mmol / L的妇女有过多的胎儿生长,妊娠高血压或剖宫产。

结论世卫组织2013年GDM的FVPG阈值不适用于丹麦。它不恰当地将患有严重糖尿病的女性标记为患有妊娠并发症绝对风险较低的大量女性。

更新日期:2018-06-22
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