Tau phosphorylation has come into the limelight again, this time as a critical player in the earliest stages of dementia pathology. Mislocalization of phosphorylated tau to dendritic spines and the resultant degeneration of synapses are observed across multiple neurodegenerative diseases, even in the absence of tau aggregation. Moreover, other molecules phosphorylated by the same kinases, such as MARCKS, might contribute to ultra-early phase pathology by promoting synapse dysfunction.

中文翻译：

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弥合多种痴呆

Tau磷酸化再次成为人们关注的焦点，这次是痴呆症病理学早期阶段的关键角色。即使在没有tau聚集的情况下，也可以在多种神经退行性疾病中观察到磷酸化的tau在树突棘中的定位错误以及突触的变性。此外，被相同激酶磷酸化的其他分子，例如MARCKS，可能通过促进突触功能障碍而促进超早期阶段病理。