Vascular endothelial growth factor (VEGF) is a key regulator of vascular formation and a predominant protein biomarker in cancer angiogenesis. Owing to its crucial roles in the cancer metastasis, VEGF detection and quantification is of great importance in clinical diagnostics. Today, there exist a wide variety of detection strategies for identifying many types of disease biomarkers, especially for VEGF. As artificial single-stranded DNA or RNA oligonucleotides with catalytic and receptor properties, aptamers have drawn lots of attention to be applied in biosensing platforms due to their target-induced conformational changes as well as high stability and target versatility. So far, various sensitivity-enhancement techniques in combination with a broad range of smart nanomaterials have integrated into the design of novel aptasensors to improve detection limit and sensitivity of analyte detection. This review article provides a brief classification and description of the research progresses of aptamer-based biosensors and nanobiosensors for the detection and quantitative determination of VEGF based on optical and electrochemical platforms.

血管内皮生长因子（VEGF）是血管形成的关键调节剂，并且是癌症血管生成中的主要蛋白质生物标记。由于其在癌症转移中的关键作用，VEGF的检测和定量在临床诊断中非常重要。如今，存在各种各样的检测策略，可用于识别多种类型的疾病生物标记物，尤其是针对VEGF的疾病生物标记物。作为具有催化和受体特性的人工单链DNA或RNA寡核苷酸，适体由于其靶标诱导的构象变化以及高稳定性和靶标多用途性而引起了人们在生物传感平台中的广泛关注。至今，各种灵敏性增强技术与广泛的智能纳米材料相结合，已被集成到新型适体传感器的设计中，以提高检测限和分析物检测的灵敏性。这篇综述文章对基于适体的生物传感器和纳米生物传感器的研究进展进行了简要的分类和描述，这些传感器用于基于光学和电化学平台的VEGF的检测和定量测定。