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High Salt Intake Attenuates Breast Cancer Metastasis to Lung
Journal of Agricultural and Food Chemistry ( IF 6.1 ) Pub Date : 2018-03-19 00:00:00 , DOI: 10.1021/acs.jafc.7b05923
Yijuan Xu 1, 2 , Wenzhe Wang 1, 2 , Minmin Wang 1, 2 , Xuejiao Liu 3 , Mee-Hyun Lee 3 , Mingfu Wang 4 , Hao Zhang 1, 2 , Haitao Li 1, 2 , Wei Chen 1, 2, 5
Affiliation  

Diet-related factors are thought to modify the risk of cancers, while the influence of high salt intake remains largely uncharacterized. Breast cancer is the most common cancer in women worldwide. In the present study, we examined the effect of salt intake on breast cancer by using a 4T1 mouse mammary tumor model. Unexpectedly, both the fitness and the survival rate of the tumor-bearing mice were improved by high salt intake. Similarly, high salt intake suppressed the primary tumor growth as well as metastasis to lung in mice. Mechanistically, high salt intake greatly reduced food intake and thus might exert antitumor effect through mimicking calorie restriction. Immunoblotting showed the lower proliferation marker Ki-67 and the higher expression of the tumor suppressor gene p53 in tumors of high salt intake mice. Importantly, high salt intake might induce hyperosmotic stress, which sensitized breast cancer cells to p53-dependent anoikis. Collectively, our findings raise the possibility that endogenous salt deposition might act as the first-line defense system against breast cancer progression as well as metastasis.

中文翻译:

高盐摄入量可减轻乳腺癌向肺的转移

人们认为与饮食相关的因素会改变罹患癌症的风险,而高盐摄入量的影响仍未有定论。乳腺癌是全世界女性中最常见的癌症。在本研究中,我们通过使用4T1小鼠乳腺肿瘤模型检查了盐摄入对乳腺癌的影响。出乎意料的是,高盐摄入量可改善荷瘤小鼠的健康和存活率。同样,高盐摄入抑制了小鼠的原发性肿瘤生长以及向肺的转移。从机械上讲,高盐摄入量会大大减少食物摄入量,因此可能会通过模仿卡路里限制来发挥抗肿瘤作用。免疫印迹显示高盐摄入小鼠的肿瘤中较低的增殖标记Ki-67和较高的抑癌基因p53表达。重要的,高盐摄入量可能会引起高渗应激,从而使乳腺癌细胞对p53依赖的神经过敏症敏感。总的来说,我们的发现增加了内源性盐沉积可能作为抵抗乳腺癌进展和转移的一线防御系统的可能性。
更新日期:2018-03-19
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