A high yield of exopolysaccharides bacteria isolated from mangrove system was identified as Bacillus atrophaeus by 16S rDNA and named as WYZ strain. An exopolysaccharide (BPS) was obtained from this strain after purification with a yield of about 0.58 g/L. Then some physical and chemical properties of BPS, such as weight average molecular weight (Mw), monosaccharide composition, intrinsic viscosity and water retention capacity were studied. The microstructure (SEM) showed that BPS was porous wound three-dimensional spider web structure. Using BPS as transdermal absorption enhancer, and lidocaine as a test drug, in vitro and local anesthesia in live animals experiments were conducted to explore that the BPS promote lidocaine transdermal absorption and mechanism. In conclusion, the BPS had good water retention capacity and transdermal absorption promoting effect, all of these indicated that BPS has great potential in the field of biomaterials.

从红树林系统中分离出的高产胞外细菌被鉴定为萎缩芽孢杆菌由16S rDNA命名为WYZ菌株。纯化后从该菌株获得胞外多糖（BPS），产率约0.58g / L。然后研究了BPS的一些物理和化学性质，例如重均分子量（Mw），单糖组成，特性粘度和保水能力。显微组织（SEM）表明，BPS是多孔缠绕​​的三维蜘蛛网结构。以BPS为透皮吸收促进剂，利多卡因为试验药物，在活体动物的体外和局部麻醉实验中探索了BPS促进利多卡因透皮吸收及其机制。总之，BPS具有良好的保水能力和促进透皮吸收的作用，所有这些表明BPS在生物材料领域具有巨大的潜力。