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Triple-negative breast cancers — a panoply of cancer types
Nature Reviews Clinical Oncology ( IF 78.8 ) Pub Date : 2018-03-19 , DOI: 10.1038/s41571-018-0001-7
Fresia Pareja , Jorge S. Reis-Filho

Triple-negative breast cancers — a panoply of cancer types

Triple-negative breast cancers — a panoply of cancer types, Published online: 19 March 2018; doi:10.1038/s41571-018-0001-7

The biological complexity of triple-negative breast cancers (TNBCs) and the lack of highly recurrent targetable genetic alterations pose major challenges for the implementation of targeted therapies for this disease. A recent multiomic in silico study has identified genetic drivers of five different TNBC molecular subtypes, providing new opportunities for precision medicine approaches.


中文翻译:

三阴性乳腺癌-多种癌症

三阴性乳腺癌-多种癌症

三阴性乳腺癌-多种癌症类型,在线发布:2018年3月19日; doi:10.1038 / s41571-018-0001-7

三阴性乳腺癌(TNBCs)的生物学复杂性以及缺乏高度复发的可靶向遗传改变为实施针对该疾病的靶向疗法提出了重大挑战。最近的一项计算机基因组学研究已经确定了五种不同TNBC分子亚型的遗传驱动因素,为精密医学方法提供了新的机会。
更新日期:2018-03-20
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