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Boric Ester and Thiourea as Coupling Partners in a Copper-Mediated Oxidative Dehydrosulfurative Carbon–Oxygen Cross-Coupling Reaction
Organic Letters ( IF 5.2 ) Pub Date : 2018-03-19 00:00:00 , DOI: 10.1021/acs.orglett.8b00502
Hyeji Kim 1 , Jihong Lee 1 , Hyunik Shin 2 , Jeong-Hun Sohn 1
Affiliation  

A copper-mediated oxidative dehydrosulfurative carbon–oxygen cross-coupling reaction with boric ester and six-membered cyclic thiourea for single-step production of densely substituted 2-alkoxypyrimidines incorporated in a privileged scaffold is described. This is the first demonstration of boric ester acting as an alkoxy donor in a metal-catalyzed coupling reaction to produce ether. The reaction method offers a shortcut for producing 2-alkoxypyrimidine derivatives with rapid diversification and expands the utility of boric ester and the scope of Liebeskind–Srogl-type reactions.

中文翻译:

硼酸酯和硫脲在铜介导的氧化脱氢硫碳-氧交叉偶联反应中作为偶联伙伴

描述了一种与硼酸酯和六元环硫脲进行铜介导的氧化脱氢硫碳-氧交叉偶联反应,用于一步制备高密度取代的2-烷氧基嘧啶的方法,该方法被并入了优先的支架中。这是硼酸酯在金属催化的偶合反应中生成醚的过程中首次证明烷氧基供体。该反应方法为快速多样化生产2-烷氧基嘧啶衍生物提供了捷径,并扩大了硼酸酯的应用范围和Liebeskind-Srogl型反应的范围。
更新日期:2018-03-19
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