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Ciprofloxacin vs. temperature: Antibiotic toxicity in the free-floating liverwort Ricciocarpus natans from a climate change perspective
Chemosphere ( IF 8.8 ) Pub Date : 2018-03-19 , DOI: 10.1016/j.chemosphere.2018.03.048
Marcelo Pedrosa Gomes , Júlio César Moreira de Brito , Elisa Monteze Bicalho , Janaína Guernica Silva , Maria de Fátima Gomides , Queila Souza Garcia , Cleber Cunha Figueredo

The physiological responses of the aquatic liverwort Ricciocarpus natans to ciprofloxacin (Cipro) exposure under different growth temperatures were investigated. Cipro appears to act as an inhibitor of mitochondrial Complex III by blocking the oxidation of quinol, resulting in the formation of hydrogen peroxide (H2O2). H2O2 accumulation upon Cipro exposure is responsible for decreased photosynthesis in plants. The amount of H2O2 in plants is kept under control by antioxidant enzymes, whose activities are central to the responses of plants to Cipro yet are influenced by temperature. Increased temperature favored Cipro uptake by plants as well as its deleterious effects on mitochondrial activity; however, it also favored the activity of antioxidant enzymes, thereby preventing the exacerbation of the deleterious effects of Cipro. The uptake of Cipro by plants appears to be largely a passive process, although some uptake must be driven by an energy-consuming process. Ricciocarpus natans should be considered for programs aimed at the reclamation of Cipro since this plant exhibits high Cipro-tolerance, the capacity for accumulation and increased uptake rates of the antibiotic with increasing temperatures (from 20 to 30 °C).



中文翻译:

环丙沙星温度的关系:从气候变化的角度看自由漂浮的艾蒿中的抗生素毒性

研究了不同生长温度下水形艾草水母麦对环丙沙星(Cipro)暴露的生理响应。Cipro似乎通过阻止喹诺醇的氧化而充当线粒体复合物III的抑制剂,从而导致过氧化氢(H 2 O 2)的形成。暴露于Cipro时H 2 O 2积累是造成植物光合作用降低的原因。H 2 O 2的量植物中的抗氧化剂被抗氧化酶所控制,抗氧化酶的活性对于植物对Cipro的反应至关重要,但受温度的影响。温度升高有利于植物吸收Cipro及其对线粒体活性的有害影响;然而,它也有利于抗氧化酶的活性,从而防止了Cipro的有害作用加剧。尽管某些吸收必须由耗能的过程驱动,但植物对Cipro的吸收似乎在很大程度上是一个被动过程。旨在对Cipro进行复垦的计划应考虑使用Ricciocarpus natans,因为该植物表现出高的Cipro耐受性,随着温度升高(从20到30°C)而积累的能力和增加的抗生素吸收率。

更新日期:2018-03-19
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