Here, we established a reversible light-responsive assembly system, which consisted of azobenzene grafted mesoporous silica nanoparticles (MSN–AZO) and cyclodextrin-functionalized Au nanoparticles (AuNP@CD). The assembly system was constructed by the host–guest interaction between azobenzene and β-cyclodextrin. For controlled release, the cargo molecule fluorescein isothiocyanate (FITC) in the pores of the MSNs can be regulated or triggered by different wavelengths. Under visible light irradiation, the azobenzene on the MSN surface exhibits a trans-configuration, and can bind with β-cyclodextrin on the AuNPs by host–guest interaction. Thus the mesopores were closed by the AuNP@CD caps and cargo molecules were locked in the pores. While under UV irradiation, the azobenzene changed to cis-configuration, which cannot bind with β-cyclodextrin, leading to the disaggregation of the caps from the outer surface of the MSNs. Thus the cargo molecules were released from the pores. This light-responsive triggered system may have potential applications in drug-controlled release, light-responsive devices and novel catalytic processes.

中文翻译：

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基于主客互动的可逆光响应装配系统，用于受控释放

在这里，我们建立了一个可逆的光响应组装系统，该系统由偶氮苯接枝的介孔二氧化硅纳米粒子（MSN–AZO）和环糊精官能化的金纳米粒子（AuNP @ CD）组成。组装系统是由偶氮苯和β-环糊精之间的主客体相互作用构建的。为了控制释放，MSN孔中的货物分子异硫氰酸荧光素（FITC）可以通过不同的波长来调节或触发。在可见光照射下，MSN表面的偶氮苯表现出反式构型，并可以通过宿主与客体的相互作用与AuNPs上的β-环糊精结合。因此，中孔被AuNP @ CD帽封闭，货物分子被锁定在孔中。在紫外线照射下，偶氮苯变为顺式-构型，其不能与β-环糊精结合，导致帽从MSN的外表面解聚。因此，货物分子从孔中释放出来。该光响应触发系统可能在药物控制释放，光响应设备和新型催化过程中具有潜在的应用。