当前位置: X-MOL 学术Food Funct. › 论文详情
Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)
Anti-anemia effects of ginsenoside Rk3 and ginsenoside Rh4 on mice with ribavirin-induced anemia
Food & Function ( IF 6.1 ) Pub Date : 2018-03-19 00:00:00 , DOI: 10.1039/c8fo00368h
Bo Wei 1, 2, 3, 4, 5 , Zhiguang Duan 1, 2, 3, 4, 5 , Chenhui Zhu 1, 2, 3, 4, 5 , Jianjun Deng 1, 2, 3, 4, 5 , Daidi Fan 1, 2, 3, 4, 5
Affiliation  

Ginsenoside Rk3 (Rk3) and ginsenoside Rh4 (Rh4) have been reported to have therapeutic effects on a variety of diseases including some hematological diseases. The aim of the present study was to treat ribavirin-induced anemia in mice with Rk3 and Rh4 and explore the therapeutic mechanisms. All the experimental mice were randomly divided into 10 groups (the normal group, the control group, the model group, the erythropoietin (EPO) group, and 6 groups of different doses of Rk3 and Rh4, n = 10 per group). The changes in the hemograms, the content of cytokines, the number of hematopoietic cells and viscera damage were observed in the experiment. The results showed that the red blood cell count, the hemoglobin amount and the hematocrit of mice in the ginsenoside groups could be restored to normal values in a short time, and the effects of both Rk3 and Rh4 are obviously better than those of EPO. Moreover, some positive regulators (EPO, erythroid transcription factor-1, and interleukin-3) related to hematopoiesis increased and some negative regulators (interferon-γ and tumour necrosis factor-α) decreased in vivo after the injection of Rk3 or Rh4. These two ginsenosides did little damage to viscera and produced different degrees of increase in the hematopoietic cells in the bone marrow and spleen, which indicated that Rk3 promoted bone marrow and extramedullary haematopoiesis while Rh4 promoted extramedullary hematopoiesis. Therefore, both Rk3 and Rh4 could be considered new therapeutic drugs for treating anemia.

中文翻译:

人参皂苷Rk3和人参皂苷Rh4对利巴韦林致贫血小鼠的抗贫血作用

人参皂苷Rk3(Rk3)和人参皂苷Rh4(Rh4)已被报道对包括某些血液病在内的多种疾病具有治疗作用。本研究的目的是治疗Rk3和Rh4小鼠的病毒唑引起的贫血,并探讨其治疗机制。将所有实验小鼠随机分为10组(正常组,对照组,模型组,促红细胞生成素(EPO)组和6组不同剂量的Rk3和Rh4,n=每组10个)。实验观察了血栓的变化,细胞因子的含量,造血细胞的数量和内脏的损害。结果表明,人参皂苷组小鼠的红细胞计数,血红蛋白量和血细胞比容可以在短时间内恢复到正常值,Rk3和Rh4的作用均明显优于EPO。此外,体内与造血相关的一些正向调节因子(EPO,类红细胞转录因子-1和白介素-3)增加,而一些负向调节因子(干扰素-γ和肿瘤坏死因子-α)降低注射Rk3或Rh4之后。这两种人参皂甙对内脏的损害很小,并且在骨髓和脾脏中造血细胞产生不同程度的增加,这表明Rk3促进了骨髓和髓外造血作用,而Rh4促进了髓外造血作用。因此,Rk3和Rh4均可被视为治疗贫血的新治疗药物。
更新日期:2018-03-19
down
wechat
bug