Compared to their differentiated progeny, stem cells are often characterized by distinct metabolic landscapes that emphasize anaerobic glycolysis and a lower fraction of mitochondrial carbohydrate oxidation. Until recently, the metabolic program of stem cells had been thought to be a byproduct of the environment, rather than an intrinsic feature determined by the cell itself. However, new studies highlight the impact of metabolic behavior on the maintenance and function of intestinal stem cells and hair follicle stem cells. This Review summarizes and discusses the evidence that metabolism is not a mere consequence of, but rather influential on stem cell fate.

中文翻译：

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这个力量很强大：新陈代谢（过度）为干细胞命运提供动力

与其分化的后代相比，干细胞的特征通常在于强调无氧糖酵解和较低比例的线粒体碳水化合物氧化的不同代谢景观。直到最近，干细胞的代谢程序一直被认为是环境的副产品，而不是由细胞本身决定的内在特征。然而，新的研究强调了代谢行为对肠道干细胞和毛囊干细胞的维持和功能的影响。这篇综述总结并讨论了新陈代谢不仅仅是干细胞命运的结果，而且对干细胞命运有影响的证据。