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Shared Functions of Perirhinal and Parahippocampal Cortices: Implications for Cognitive Aging
Trends in Neurosciences ( IF 15.9 ) Pub Date : 2018-06-01 , DOI: 10.1016/j.tins.2018.03.001
Sara N Burke 1 , Leslie S Gaynor 2 , Carol A Barnes 3 , Russell M Bauer 4 , Jennifer L Bizon 5 , Erik D Roberson 6 , Lee Ryan 7
Affiliation  

A predominant view of perirhinal cortex (PRC) and postrhinal/parahippocampal cortex (POR/PHC) function contends that these structures are tuned to represent objects and spatial information, respectively. However, known anatomical connectivity, together with recent electrophysiological, neuroimaging, and lesion data, indicate that both brain areas participate in spatial and nonspatial processing. Instead of content-based organization, the PRC and PHC/POR may participate in two computationally distinct cortical-hippocampal networks: one network that is tuned to process coarse information quickly, forming gist-like representations of scenes/environments, and a second network tuned to process information about the specific sensory details that are necessary for discrimination across sensory modalities. The available data suggest that the latter network may be more vulnerable in advanced age.

中文翻译:

鼻周和海马旁皮质的共同功能:对认知衰老的影响

鼻周皮层(PRC)和鼻后/海马旁皮层(POR/PHC)功能的主流观点认为,这些结构分别被调整来表示物体和空间信息。然而,已知的解剖连接性以及最近的电生理学、神经影像学和病变数据表明,两个大脑区域都参与空间和非空间处理。PRC 和 PHC/POR 可能参与两个计算上不同的皮质海马网络,而不是基于内容的组织:一个网络被调整为快速处理粗略信息,形成场景/环境的要点状表示,第二个网络被调整处理有关区分不同感官模式所必需的特定感官细节的信息。现有数据表明,后者网络在高龄时可能更容易受到攻击。
更新日期:2018-06-01
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