Flexible and implantable glucose biosensors are emerging technologies for continuous monitoring of blood-glucose of diabetes. Developing a flexible conductive substrates with high active surface area is critical for advancing the technology. Here, we successfully fabricate a flexible and highly sensitive nonenzymatic glucose by using DVD-laser scribed graphene (LSG) as a flexible conductively substrate. Copper nanoparticles (Cu-NPs) are electrodeposited as the catalyst. The LSG/Cu-NPs sensor demonstrates excellent catalytic activity toward glucose oxidation and exhibits a linear glucose detection range from 1 μM to 4.54 mM with high sensitivity (1.518 mA mM⁻¹ cm⁻²) and low limit of detection (0.35 μM). Moreover, the LSG/Cu-NPs sensor shows excellent reproducibility and long-term stability. It is also highly selective toward glucose oxidation under the presence of various interfering species. Excellent flexing stability is also demonstrated by the LSG/Cu-NPs sensor, which is capable of maintaining 83.9% of its initial current after being bent against a 4-mm diameter rod for 180 times. The LSG/Cu-NPs sensor shows great potential for practical application as a nonenzymatic glucose biosensor. Meanwhile, the LSG conductive substrate provides a platform for the developing next-generation flexible and potentially implantable bioelectronics and biosensors.

灵活且可植入的葡萄糖生物传感器是不断监测糖尿病血糖的新兴技术。开发具有高活性表面积的柔性导电基板对于推进该技术至关重要。在这里，我们通过使用DVD激光划刻石墨烯（LSG）作为柔性导电基材成功地制造了柔性且高度灵敏的非酶葡萄糖。铜纳米颗粒（Cu-NPs）电沉积为催化剂。LSG / Cu-NPs传感器对葡萄糖氧化表现出出色的催化活性，并具有从1μM到4.54 mM的线性葡萄糖检测范围，并具有高灵敏度（1.518 mA mM ^-1 cm ^-2）和检测下限（0.35μM）。此外，LSG / Cu-NPs传感器显示出出色的重现性和长期稳定性。在各种干扰物质的存在下，它对葡萄糖氧化的选择性也很高。LSG / Cu-NPs传感器还展示了出色的挠曲稳定性，该传感器在对直径为4毫米的杆上弯曲180次后能够保持其初始电流的83.9％。LSG / Cu-NPs传感器作为非酶葡萄糖生物传感器在实际应用中显示出巨大的潜力。同时，LSG导电基板为开发下一代柔性且可能植入的生物电子和生物传感器提供了平台。