Phototoxicity occurs when UV irradiation causes otherwise benign compounds to become irritant, sensitizers, or even genotoxic. This toxicity is particularly a concern after topical application and in dermatological programs where skin irritation can be incompatible with the desired therapeutic outcome. This brief article establishes that the intrinsic property forecast index (iPFI) can be used to evaluate the probability of a compound being phototoxic and gives medicinal chemists a practical tool to handle this liability.

中文翻译：

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本质特性预测指数（iPFI）是药用化学家消除光毒性责任的经验法则

当紫外线照射导致其他良性化合物变得刺激性，敏化剂甚至遗传毒性时，就会发生光毒性。在局部应用后以及皮肤刺激可能与所需治疗结果不相容的皮肤科程序中，这种毒性尤其令人担忧。这篇简短的文章确定了内在特性预测指数（iPFI）可用于评估化合物具有光毒性的可能性，并为药物化学家提供了处理这一责任的实用工具。