Abstract In this paper, we reported a novel continuous microwave assisted flow synthesis (CMFS) of nanosized manganese substituted hydroxyapatite particles by using calcium nitrate and diammonium hydrogen phosphate precursor solutions in only 7 min retention time at pH 9. The identification of nanoproduct was made by using X-ray diffraction (XRD), Transmission electron microscopy (TEM), Scanning electron microscopy (SEM), Dynamic light scattering (DLS), Fourier Transform Infrared Spectroscopy (FTIR) and Raman spectroscopy. The results indicated that nanosized manganese substituted hydroxyapatite particles were synthesized successfully in a shorter time period. The degree of crystallinity of the nanoproduct decreased with increasing manganese contents from 0% to 4%. At such conditions, variations in particles’ size and morphology from larger rod shaped particles (~110 nm) to smaller semispherical form (~75 nm) was observed. Thus the use of continuous microwave assisted flow synthesis procedure facilitated faster production of manganese substituted hydroxyapatite nanoparticles suitable for bone replacement applications.

中文翻译：

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纳米锰取代羟基磷灰石的新型连续微波辅助流合成

摘要 在本文中，我们报道了使用硝酸钙和磷酸氢二铵前驱体溶液在 pH 9 下仅保留 7 分钟的纳米尺寸锰取代羟基磷灰石颗粒的新型连续微波辅助流动合成 (CMFS)。使用 X 射线衍射 (XRD)、透射电子显微镜 (TEM)、扫描电子显微镜 (SEM)、动态光散射 (DLS)、傅里叶变换红外光谱 (FTIR) 和拉曼光谱。结果表明，在较短的时间内成功合成了纳米尺寸的锰取代羟基磷灰石颗粒。随着锰含量从 0% 增加到 4%，纳米产品的结晶度降低。在这样的条件下，观察到颗粒大小和形态从较大的棒状颗粒（~110 nm）到较小的半球形（~75 nm）的变化。因此，连续微波辅助流动合成程序的使用促进了适用于骨替代应用的锰取代羟基磷灰石纳米颗粒的更快生产。