Two multicentre, randomised trials assessed whether severe asthma exacerbations could be prevented by substantially increasing the daily dose of inhaled glucocorticoids at the first symptoms of loss of asthma control (the “yellow zone”). The results indicated that this common practice might not be helpful in preventing exacerbations in children but might be beneficial to some adults, although with increased adverse events.

中文翻译：

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糖皮质激素增加对哮喘加重的影响

两项多中心的随机试验评估了在哮喘控制丧失的最初症状（“黄色区域”）出现时，通过大幅增加每日吸入糖皮质激素的剂量是否可以预防严重的哮喘加重。结果表明，这种常见做法可能无助于预防儿童病情加重，但对某些成年人可能有益，尽管不良事件增加了。