Biochimie ( IF 3.9 ) Pub Date : 2018-03-16 , DOI: 10.1016/j.biochi.2018.03.006 Nuno Couto , Sergio Caja , Joana Maia , Maria Carolina Strano Moraes , Bruno Costa-Silva
Oncologic diseases do not behave as isolated entities. Instead, they are based on complex systemic networks involving cell-cell communication between cancerous and healthy cells of the host, which may either facilitate or prevent cancer progression. In addition to cell-cell contacts, cells communicate through secreted factors in a process modulated by ligand concentration, receptor availability and synergy amongst several signaling circuits. Of these secreted factors, exosomes, 30–150 nm membrane vesicles of endocytic origin released by virtually all cells, have emerged as important cell-cell communication players both in physiological and pathological scenarios by being carriers of all the main biomolecules, including lipids, proteins, DNAs, messenger RNAs and microRNA, and performing intercellular transfer of components, locally and systemically. By acting both in tumor and non-tumor cells, such as fibroblasts, leukocytes, endothelial and progenitor cells, tumor- and non-tumor cells-derived exosomes can modulate tumor growth and invasion, tumor-associated angiogenesis, tissue inflammation and the immune system. In this Review, we summarize the main findings of the literature on the roles of exosomes in mediating interactions between tumor and tumor-associated cells. We also discuss how the molecular composition analysis of circulating exosomes in clinical settings has emerged as an attractive non-invasive source of liquid biopsies for early diagnosis, prognosis and follow-up of patients with oncologic diseases.
中文翻译:
外来体在癌症生物学中是新兴的参与者
肿瘤疾病并不表现为孤立的实体。相反,它们基于复杂的系统网络,该系统涉及宿主的癌细胞与健康细胞之间的细胞间通信,这可能促进或阻止癌症的进展。除了细胞与细胞之间的接触外,细胞还通过分泌因子进行通讯,该过程由配体浓度,受体可用性和几种信号传导回路之间的协同作用调节。在这些分泌因子中,外泌体,实际上是所有细胞释放的内吞起源的30-150 nm膜囊泡,已成为所有主要生物分子(包括脂质,蛋白质)的载体,在生理和病理情况下均已成为重要的细胞-细胞通讯参与者。 ,DNA,信使RNA和microRNA,并在局部和系统范围内进行组分的细胞间转移。通过同时作用于成纤维细胞,白细胞,内皮细胞和祖细胞等肿瘤细胞和非肿瘤细胞,肿瘤和非肿瘤细胞衍生的外来体可以调节肿瘤的生长和侵袭,与肿瘤相关的血管生成,组织炎症和免疫系统。在这篇综述中,我们总结了外泌体在介导肿瘤与肿瘤相关细胞之间相互作用中的作用的文献的主要发现。我们还将讨论在临床环境中循环外泌体的分子组成分析如何作为液体活检的有吸引力的非侵入性来源而出现,用于肿瘤疾病患者的早期诊断,预后和随访。肿瘤和非肿瘤细胞衍生的外来体可以调节肿瘤的生长和侵袭,肿瘤相关的血管生成,组织炎症和免疫系统。在这篇综述中,我们总结了外泌体在介导肿瘤与肿瘤相关细胞之间相互作用中作用的文献的主要发现。我们还将讨论在临床环境中循环外泌体的分子组成分析如何作为液体活检的有吸引力的非侵入性来源而出现,用于肿瘤疾病患者的早期诊断,预后和随访。肿瘤和非肿瘤细胞衍生的外来体可以调节肿瘤的生长和侵袭,肿瘤相关的血管生成,组织炎症和免疫系统。在这篇综述中,我们总结了外泌体在介导肿瘤与肿瘤相关细胞之间相互作用中作用的文献的主要发现。我们还将讨论在临床环境中循环外泌体的分子组成分析如何作为液体活检的有吸引力的非侵入性来源而出现,用于肿瘤疾病患者的早期诊断,预后和随访。